Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL504216 | 0.86 | CA12 (0.46) | TAS2R14LMNAGAAALDH1A1HPGD | |
| SCHEMBL28107141 | 0.83 | SMN1; SMN2 (0.44) | TAS2R14SMN1; SMN2LMNAGAARORC | |
| SCHEMBL23908702 | 0.82 | ALDH1A1 (0.51) | TAS2R14LMNAGAAALDH1A1HPGD | |
| SCHEMBL570378 | 0.79 | CA12 (0.52) | LMNAALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL503596 | 0.78 | CES2 (0.50) | TAS2R14ALDH1A1HPGDRORC | |
| SCHEMBL24277954 | 0.78 | CA12 (0.61) | TAS2R14ALDH1A1HPGDCA1CA2 | |
| SCHEMBL2964734 | 0.78 | TAS2R14 (0.51) | TAS2R14LMNAGAAALDH1A1HPGD | |
| SCHEMBL5322102 | 0.78 | PRNP (0.37) | TAS2R14HPGDMAPTKMT2AL3MBTL1 | |
| SCHEMBL31189227 | 0.78 | PRNP (0.37) | TAS2R14HPGDMAPTKMT2AL3MBTL1 | |
| SCHEMBL1486789 | 0.77 | LMNA (0.44) | TAS2R14LMNAGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-04-06 | — | — | US | disclosed |
| CN-106928113-B | Cathepsin K inhibitors and uses thereof | 广东东阳光药业有限公司 | 2020-07-07 | — | — | CN | disclosed |
| EP-3207008-B1 | PROCESS FOR THE PREPARATION OF 5-BROMO-1,2,3-TRICHLOROBENZENE | SYNGENTA PARTICIPATIONS AG (CH) | 2018-07-25 | — | — | EP | disclosed |
| US-9975823-B2 | Process for the preparation of 5-bromo-1,2,3-trichlorobenzene | SYNGENTA PARTICIPATIONS AG (CH) | 2018-05-22 | — | — | US | disclosed |
| US-20170267611-A1 | PROCESS FOR THE PREPARATION OF 5-BROMO-1,2,3-TRICHLOROBENZENE | SYNGENTA PARTICIPATIONS AG (CH) | 2017-09-21 | — | — | US | disclosed |
| US-20170267611-A1 | PROCESS FOR THE PREPARATION OF 5-BROMO-1,2,3-TRICHLOROBENZENE | SYNGENTA PARTICIPATIONS AG (CH) | 2017-09-21 | — | — | US | disclosed |
| WO-2016058897-A1 | PROCESS FOR THE PREPARATION OF 5-BROMO-1,2,3-TRICHLOROBENZENE | SYNGENTA PARTICIPATIONS AG (CH) | 2016-04-21 | — | — | WO | disclosed |
| US-20120277279-A1 | Non-Steroidal Glucocorticoid Inhibitors and Their Use in Treating Inflammation, Allergy and Auto-Immune Conditions | GLAXO GROUP LIMITED | 2012-11-01 | — | — | US | disclosed |
| US-8247377-B2 | Non-steroidal glucocorticoid inhibitors and their use in treating inflammation, allergy and auto-immune conditions | GLAXO GROUP LIMITED (GB) | 2012-08-21 | — | — | US | disclosed |
| EP-2029549-B1 | PHENYL-PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORICOID RECEPTOR LIGANDS | GLAXO GROUP LTD (GB) | 2010-11-10 | — | — | EP | disclosed |
| US-20100234441-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | US | disclosed |
| EP-2029549-A2 | PHENYL-PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORICOID RECEPTOR LIGANDS | Glaxo Group Limited (GB) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007144327-A2 | PHENYL-PYRAZOLE DERIVATIVES AS NON-STEROIDAL GLUCOCORICOID RECEPTOR LIGANDS | GLAXO GROUP LIMITED (GB) | 2007-12-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234441-A1 | NOVEL COMPOUNDS | LTB4R2, TSLP, LTB4R | TAS2R14 2856/4885SMN1; SMN2 4171/4885LMNA 4013/4885 |
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | SCN8A, SCN1A, SCN1B | TAS2R14 1406/4885SMN1; SMN2 195/4885LMNA 686/4885 |
| US-20170267611-A1 | PROCESS FOR THE PREPARATION OF 5-BROMO-1,2,3-TRICHLOROBENZENE | TERT, CYP1B1, KAT5 | TAS2R14 2303/4885SMN1; SMN2 3465/4885LMNA 2515/4885 |
| US-20120277279-A1 | Non-Steroidal Glucocorticoid Inhibitors and Their Use in Treating Inflammation, Allergy and Auto-Immune Conditions | NR3C1, SERPINA6, PTGS1 | TAS2R14 4323/4885SMN1; SMN2 4794/4885LMNA 4343/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.