Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28783842 | 0.87 | AOC3 (0.33) | APOBEC3GGABRA1GABRG2GABRB3PDCD1 | |
| SCHEMBL21806628 | 0.80 | CYP4F2 (0.41) | APOBEC3GGABRA1GABRG2GABRB3PDCD1 | |
| SCHEMBL29156112 | 0.80 | APOBEC3G (0.36) | APOBEC3GGABRA1GABRG2GABRB3PDCD1 | |
| SCHEMBL26620310 | 0.79 | ALDH1A1 (0.34) | ALDH1A1AOC3TSHRIDO1FABP4 | |
| SCHEMBL4367933 | 0.78 | GABRA1 (0.45) | GABRA1ALDH1A1CYP3A4ALOX15CYP2C19 | |
| SCHEMBL17864869 | 0.77 | ESR1 (0.40) | GABRA1GABRG2GABRB3ALDH1A1CYP3A4 | |
| SCHEMBL23257382 | 0.76 | POLB (0.41) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL31039404 | 0.76 | POLB (0.41) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL9601379 | 0.76 | DPP4 (0.39) | PDCD1CD274ALDH1A1CYP2C19L3MBTL1 | |
| SCHEMBL357956 | 0.76 | GABRA1 (0.58) | APOBEC3GGABRA1GABRG2GABRB3PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110891951-B | Compounds of formula (I) | 谢菲尔德大学 | 2024-08-20 | — | — | CN | disclosed |
| EP-3628045-B1 | COMPOUNDS | UNIV SHEFFIELD (GB) | 2024-07-03 | — | — | EP | disclosed |
| US-20210113534-A1 | COMPOUNDS | THE UNIVERSITY OF SHEFFIELD (GB) | 2021-04-22 | — | — | US | disclosed |
| CN-110891951-A | Compound (I) | 谢菲尔德大学 | 2020-03-17 | — | — | CN | disclosed |
| US-9944663-B2 | Process for preparing substituted pentacenes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2018-04-17 | — | — | US | disclosed |
| US-20120305854-A1 | PROCESS FOR PREPARING SUBSTITUTED PENTACENES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-06 | — | — | US | disclosed |
| US-8318048-B2 | Process for preparing substituted pentacenes | MERCK PATENT GMBH (DE) | 2012-11-27 | — | — | US | disclosed |
| EP-2134725-B1 | PROCESS FOR PREPARING SUBSTITUTED PENTACENES | MERCK PATENT GMBH (DE) | 2012-07-04 | — | — | EP | disclosed |
| US-20100127220-A1 | Process for Preparing Substituted Pentacenes | MERCK PATENT GMBH (DE) | 2010-05-27 | — | — | US | disclosed |
| EP-2134725-A1 | PROCESS FOR PREPARING SUBSTITUTED PENTACENES | Merck Patent GmbH (DE) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008128618-A1 | PROCESS FOR PREPARING SUBSTITUTED PENTACENES | MERCK PATENT GMBH (DE) | 2008-10-30 | — | — | WO | disclosed |
| US-7365061-B2 | 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-04-29 | — | — | US | disclosed |
| WO-2006055463-A2 | 2-AMINO-3-FUNCTIONALIZED TETRALIN DERIVATIVES AND RELATED GLYCOGEN PHOSPHORYLASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-26 | — | — | WO | disclosed |
| US-20060111413-A1 | Antidiabetic agents, anticancer, non-cardiac ischemia, infection, hypertension, obesity and dislipidemia; 3-(5-chloroindole-2-carbonylamino)-2-hydroxy-1,2,3,4-tetrahydronaphthalene | BRISTOL-MYERS SQUIBB COMPANY | 2006-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100127220-A1 | Process for Preparing Substituted Pentacenes | FES, PFAS, SLC46A1 | APOBEC3G 4635/4885GABRA1 4129/4885GABRG2 4389/4885 |
| US-20120305854-A1 | PROCESS FOR PREPARING SUBSTITUTED PENTACENES | FES, PFAS, SLC46A1 | APOBEC3G 4635/4885GABRA1 4129/4885GABRG2 4389/4885 |
| US-20210113534-A1 | COMPOUNDS | MRGPRX2, MC2R, ADM2 | APOBEC3G 4088/4885GABRA1 3215/4885GABRG2 3115/4885 |
| US-20060111413-A1 | Antidiabetic agents, anticancer, non-cardiac ischemia, infection, hypertension, obesity and dislipidemia; 3-(5-chloroindole-2-carbonylamino)-2-hydroxy-1,2,3,4-tetrahydronaphthalene | PYGM, PON1, GYS1 | APOBEC3G 4683/4885GABRA1 4878/4885GABRG2 4885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.