Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.34 |
| ▸ | RORC | P51449 | 2/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.31 |
| ▸ | MLNR | O43193 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
| ▸ | IKBKB | O14920 | 2/20 | 0.30 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454499 | 0.75 | HTR6 (0.33) | RORCPLATPSIP1MLNRCYP2D6 | |
| SCHEMBL22324769 | 0.69 | SLC18A3 (0.48) | RORCPSIP1HTR6 | |
| SCHEMBL3454494 | 0.68 | GABRA2 (0.33) | CNR2RORCPLATJAK2HTR6 | |
| SCHEMBL3072064 | 0.68 | SYK (0.44) | RORCPLATMLNRCYP2D6JAK2 | |
| SCHEMBL3454570 | 0.64 | NMT1 (0.33) | PLATHTR6 | |
| SCHEMBL5051360 | 0.63 | RORC (0.60) | RORCCA1CA2PTGS1PTGS2 | |
| SCHEMBL4777240 | 0.62 | GBA1 (0.54) | CNR2RORCPSIP1MLNRHTR6 | |
| SCHEMBL10181940 | 0.61 | RORC (0.62) | CNR2RORCPSIP1 | |
| Hydrochloric Acid SCHEMBL4773264 | 0.61 | GBA1 (0.53) | CNR2RORCPSIP1MLNRHTR6 | |
| SCHEMBL3454502 | 0.60 | PSIP1 (0.34) | PSIP1MLNRCYP2D6JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166850-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | High Point Pharmaceuticals, LLC (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008154126-A1 | NEW HETEOCYCLIC H3 ANTAGONISTS | HIGH POINT PHARMACEUTICALS, LLC (US) | 2008-12-18 | — | — | WO | disclosed |