Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL84268 | 0.74 | CYP3A4 (0.41) | TSHRALDH1A1L3MBTL1SMN1; SMN2MAPK1 | |
| SCHEMBL23735874 | 0.74 | L3MBTL1 (0.38) | TSHRL3MBTL1SMN1; SMN2MAPK1SLC6A2 | |
| SCHEMBL807524 | 0.73 | TSHR (0.46) | TSHRALDH1A1L3MBTL1SMN1; SMN2MAPK1 | |
| SCHEMBL15417412 | 0.72 | TSHR (0.38) | TSHRALDH1A1L3MBTL1SMN1; SMN2MAPK1 | |
| SCHEMBL483553 | 0.72 | CYP19A1 (0.46) | TSHRALDH1A1SMN1; SMN2RAB9AGALR3 | |
| SCHEMBL28044155 | 0.71 | GABRA1 (0.39) | TSHRALDH1A1L3MBTL1SMN1; SMN2MAPK1 | |
| SCHEMBL6958245 | 0.71 | CA1 (0.37) | TSHRALDH1A1SMN1; SMN2MAOBRAB9A | |
| SCHEMBL15018240 | 0.69 | NOTUM (0.36) | TSHRALDH1A1L3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL7674083 | 0.69 | TSHR (0.41) | TSHRALDH1A1RAB9AGAANPC1 | |
| SCHEMBL28046785 | 0.68 | SLC6A2 (0.43) | TSHRALDH1A1L3MBTL1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795448-B2 | Imidazoyl-benzamide anti-cancer agents | CYTOKINETICS, INCORPORATED (US) | 2010-09-14 | — | — | US | disclosed |
| US-20070197481-A1 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INCORPORATED | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197481-A1 | Certain chemical entities, compositions, and methods | KIF5B, KIF2C, PLK1 | TSHR 4714/4885ALDH1A1 2159/4885L3MBTL1 2781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.