SCHEMBL3483052

SCHEMBL3483052

Cn1ncc2c[c]cnc21

nearest known ligand 0.35

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
PI4KA P42356 1/20 0.35
PI4K2B Q8TCG2 1/20 0.35
PI4K2A Q9BTU6 1/20 0.35
PI4KB Q9UBF8 1/20 0.35
ALDH1A1 P00352 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
APP P05067 1/20 0.32
PDE2A O00408 1/20 0.32
ALOX15 P16050 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
KDM4E B2RXH2 1/20 0.31
NSD2 O96028 1/20 0.30
PKM P14618 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2398466 0.76 KDM4E (0.34) KMT2AKDM4E
SCHEMBL797323 0.68 PIK3CB (0.34) APP
SCHEMBL31194479 0.67 PI4KA (0.46) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL256376 0.67 PI4KA (0.46) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL7920028 0.65 CCR1 (0.43) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL2067409 0.65 SLC9A1 (0.36)
SCHEMBL3303776 0.64 HSD17B10 (0.46) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL16617428 0.64
SCHEMBL31752039 0.64 APP (0.47) PI4KAPI4K2BPI4K2API4KBALDH1A1
SCHEMBL30478722 0.64 APP (0.40) PI4KAPI4K2BPI4K2API4KBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230310413-A1 PHARMACEUTICAL FORMULATIONS COMPRISING A MALT1 INHIBITOR AND A MIXTURE OF POLYETHYLENE GLYCOL WITH A FATTY ACID JANSSEN PHARMACEUTICA NV (BE) 2023-10-05 US claimed
CN-115884773-A Pharmaceutical preparation 詹森药业有限公司 2023-03-31 CN claimed
CN-115210567-A Methods of assessing efficacy of MALT1 inhibitors using NF-KB translocation assays 詹森药业有限公司 2022-10-18 CN claimed
EP-4062175-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY Janssen Pharmaceutica NV (BE) 2022-09-28 EP claimed
EP-4061966-A1 NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS Janssen Pharmaceutica NV (BE) 2022-09-28 EP claimed
CN-114981453-A NF-KB regulated gene expression assay for assessing efficacy of MALT1 inhibitors 詹森药业有限公司 2022-08-30 CN claimed
US-20220175760-A1 PHARMACEUTICAL FORMULATIONS JANSSEN PHARMACEUTICA NV (BE) 2022-06-09 US claimed
CN-113473971-A Pharmaceutical formulations 詹森药业有限公司 2021-10-01 CN claimed
WO-2021099609-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 WO claimed
WO-2021099612-A1 NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 WO claimed
US-20210155990-A1 NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 US claimed
US-20210156865-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 US claimed
CN-107074822-B Triazole compounds as T-type calcium channel blockers 爱杜西亚药品有限公司 2020-01-03 CN claimed
EP-3558969-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS Janssen Pharmaceutica NV (BE) 2019-10-30 EP claimed
US-10246426-B2 Triazole compounds as T-type calcium channel blockers IDORSIA PHARMACEUTICALS LTD (CH) 2019-04-02 US claimed
US-20190071416-A1 COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2019-03-07 US claimed
EP-3194374-B1 TRIAZOLE COMPOUNDS AS T-TYPE CALCIUM CHANNEL BLOCKERS IDORSIA PHARMACEUTICALS LTD (CH) 2018-08-01 EP claimed
WO-2018119036-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN BIOTECH, INC. (US) 2018-06-28 WO claimed
US-20180170909-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN-CILAG (FR) 2018-06-21 US claimed
CN-113473971-B Pharmaceutical formulations 詹森药业有限公司 2024-07-02 CN disclosed
US-20230414629-A1 MATERIALS AND METHODS OF TREATING CANCER MONOPTEROS THERAPEUTICS, INC. 2023-12-28 US disclosed
US-20230310413-A1 PHARMACEUTICAL FORMULATIONS COMPRISING A MALT1 INHIBITOR AND A MIXTURE OF POLYETHYLENE GLYCOL WITH A FATTY ACID JANSSEN PHARMACEUTICA NV (BE) 2023-10-05 US disclosed
EP-4243812-A1 MATERIALS AND METHODS OF TREATING CANCER Monopteros Therapeutics, Inc. (US) 2023-09-20 EP disclosed
CN-116710089-A Materials and methods for treating cancer 莫诺泰罗斯疗法公司 2023-09-05 CN disclosed
US-20230235077-A1 MATERIALS AND METHODS OF TREATING CANCER THE GENERAL HOSPITAL CORPORATION (US) 2023-07-27 US disclosed
CN-115884773-A Pharmaceutical preparation 詹森药业有限公司 2023-03-31 CN disclosed
US-11571427-B2 Targeting the CBM signalosome complex induces regulatory T cells to inflame the tumor microenvironment THE GENERAL HOSPITAL CORPORATION (US) 2023-02-07 US disclosed
CN-115210567-A Methods of assessing efficacy of MALT1 inhibitors using NF-KB translocation assays 詹森药业有限公司 2022-10-18 CN disclosed
EP-4062175-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY Janssen Pharmaceutica NV (BE) 2022-09-28 EP disclosed
CN-114981453-A NF-KB regulated gene expression assay for assessing efficacy of MALT1 inhibitors 詹森药业有限公司 2022-08-30 CN disclosed
US-11401272-B2 Heterocyclic compounds as LSD1 inhibitors INCYTE CORPORATION (US) 2022-08-02 US disclosed
US-20220175760-A1 PHARMACEUTICAL FORMULATIONS JANSSEN PHARMACEUTICA NV (BE) 2022-06-09 US disclosed
WO-2022101676-A1 MATERIALS AND METHODS OF TREATING CANCER MONOPTEROS THERAPEUTICS,INC. (US) 2022-05-19 WO disclosed
WO-2021262969-A1 MATERIALS AND METHODS OF TREATING CANCER THE GENERAL HOSPITAL CORPORATION (US) 2021-12-30 WO disclosed
CN-113473971-A Pharmaceutical formulations 詹森药业有限公司 2021-10-01 CN disclosed
CN-107660205-B Heterocyclic compounds as LSD1 inhibitors 因赛特公司 2021-08-27 CN disclosed
US-20210155990-A1 NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 US disclosed
WO-2021099609-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 WO disclosed
US-20210156865-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY JANSSEN PHARMACEUTICA NV (BE) 2021-05-27 US disclosed
US-10954214-B2 Pyrazole derivatives as MALT1 inhibitors JANSSEN PHARMACEUTICA NV (BE) 2021-03-23 US disclosed
US-20210052596-A1 TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT THE GENERAL HOSPITAL CORPORATION (US) 2021-02-25 US disclosed
US-20200392143-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS INCYTE CORPORATION 2020-12-17 US disclosed
EP-3731848-A1 TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT The General Hospital Corporation (US) 2020-11-04 EP disclosed
CN-111770759-A Targeting the CBM-signalosome complex to induce regulatory T cells to inflame the tumor microenvironment 通用医疗公司 2020-10-13 CN disclosed
US-10800779-B2 Heterocyclic compounds as LSD1 inhibitors INCYTE CORPORATION (US) 2020-10-13 US disclosed
EP-3626720-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS Incyte Corporation (US) 2020-03-25 EP disclosed
CN-107074822-B Triazole compounds as T-type calcium channel blockers 爱杜西亚药品有限公司 2020-01-03 CN disclosed
EP-3558969-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS Janssen Pharmaceutica NV (BE) 2019-10-30 EP disclosed
EP-3277689-B1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS INCYTE CORP (US) 2019-09-04 EP disclosed
US-10246426-B2 Triazole compounds as T-type calcium channel blockers IDORSIA PHARMACEUTICALS LTD (CH) 2019-04-02 US disclosed
US-20190071416-A1 COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2019-03-07 US disclosed
US-20190055250-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS INCYTE CORPORATION 2019-02-21 US disclosed
EP-3194374-B1 TRIAZOLE COMPOUNDS AS T-TYPE CALCIUM CHANNEL BLOCKERS IDORSIA PHARMACEUTICALS LTD (CH) 2018-08-01 EP disclosed
WO-2018119036-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN BIOTECH, INC. (US) 2018-06-28 WO disclosed
US-20180170909-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS JANSSEN-CILAG (FR) 2018-06-21 US disclosed
US-9944647-B2 Heterocyclic compounds as LSD1 inhibitors INCYTE CORPORATION (US) 2018-04-17 US disclosed
EP-3277689-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS Incyte Corporation (US) 2018-02-07 EP disclosed
EP-3194374-A1 TRIAZOLE COMPOUNDS AS T-TYPE CALCIUM CHANNEL BLOCKERS Idorsia Pharmaceuticals Ltd (CH) 2017-07-26 EP disclosed
WO-2016161282-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS INCYTE CORPORATION (US) 2016-10-06 WO disclosed
US-20160289238-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS INCYTE CORPORATION 2016-10-06 US disclosed
WO-2016041892-A1 TRIAZOLE COMPOUNDS AS T-TYPE CALCIUM CHANNEL BLOCKERS ACTELION PHARMACEUTICALS LTD (CH) 2016-03-24 WO disclosed
US-9006225-B2 Stable pharmaceutical composition ASAHI KASEI PHARMA CORPORATION (JP) 2015-04-14 US disclosed
EP-2236135-A1 STABLE PHARMACEUTICAL COMPOSITION Asahi Kasei Pharma Corporation (JP) 2010-10-06 EP disclosed
US-20100048893-A1 Substituted arylalkanoic acid derivatives and use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2010-02-25 US disclosed
US-20100041725-A1 STABLE PHARMACEUTICAL COMPOSITION ASAHI KASEI PHARMA CORPORATION (JP) 2010-02-18 US disclosed
EP-2006271-A9 SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF Asahi Kasei Pharma Corporation (JP) 2009-07-29 EP disclosed
US-20090062530-A1 Substituted arylalkanoic acid derivatives and use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2009-03-05 US disclosed
US-20090054401-A1 Substituted bicyclic derivatives and use thereof ASAHI KASEI PHARMA CORPORATION (JP) 2009-02-26 US disclosed
US-7470807-B2 Suppress production of both prostaglandins and leukotrienes and have reduced side effects; treatment of various inflammatory diseases, autoimmune diseases, allergic diseases, pain and fibrosis; for example, methyl 3-[3-acetylamino-4-cyclopentyloxy-5-(naphthalen-2-yl)phenyl]propionate ASAHI KASEI PHARMA CORPORATION (JP) 2008-12-30 US disclosed
EP-2006271-A2 SUBSTITUTED BICYCLIC CYCLIC DERIVATIVE AND USE THEREOF Asahi Kasei Pharma Corporation (JP) 2008-12-24 EP disclosed
US-20070213333-A1 Substituted arylalkanoic acid derivatives and use thereof ASAHI KASEI PHAMA CORPORATION (JP) 2007-09-13 US disclosed
US-20070213333-A1 Substituted arylalkanoic acid derivatives and use thereof ASAHI KASEI PHAMA CORPORATION (JP) 2007-09-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (22 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11401272-B2 Heterocyclic compounds as LSD1 inhibitors KDM1B, KDM1A, DOT1L PI4KA 4134/4885PI4K2B 4182/4885PI4K2A 4312/4885
US-20090054401-A1 Substituted bicyclic derivatives and use thereof LTB4R2, LTC4S, LTB4R PI4KA 4410/4885PI4K2B 4244/4885PI4K2A 4330/4885
US-20200392143-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS KDM1B, KDM1A, DOT1L PI4KA 4134/4885PI4K2B 4182/4885PI4K2A 4312/4885
US-20190071416-A1 COMPOUNDS FOR TREATMENT OF CANCER AND EPIGENETICS SMYD3, SMYD2, EHMT1 PI4KA 3660/4885PI4K2B 3993/4885PI4K2A 4037/4885
US-20190055250-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS KDM1B, KDM1A, DOT1L PI4KA 4134/4885PI4K2B 4182/4885PI4K2A 4312/4885
US-10246426-B2 Triazole compounds as T-type calcium channel blockers CACNA1I, CACNA1E, CACNA1G PI4KA 2340/4885PI4K2B 2479/4885PI4K2A 3026/4885
US-10954214-B2 Pyrazole derivatives as MALT1 inhibitors MALT1, PPP3R1, SQSTM1 PI4KA 1711/4885PI4K2B 1587/4885PI4K2A 1834/4885
US-20210052596-A1 TARGETING THE CBM SIGNALOSOME COMPLEX INDUCES REGULATORY T CELLS TO INFLAME THE TUMOR MICROENVIRONMENT CD47, ICOS, LCK PI4KA 1798/4885PI4K2B 1872/4885PI4K2A 2099/4885
US-20210155990-A1 NF-KB REGULATED GENE EXPRESSION ASSAY FOR ASSESSING EFFICACY OF MALT1 INHIBITORS MALT1, NFKBIA, NFKB2 PI4KA 3607/4885PI4K2B 3658/4885PI4K2A 3851/4885
US-20100048893-A1 Substituted arylalkanoic acid derivatives and use thereof CYSLTR1, CYSLTR2, LTB4R2 PI4KA 3789/4885PI4K2B 4069/4885PI4K2A 3807/4885
US-20230235077-A1 MATERIALS AND METHODS OF TREATING CANCER MALT1, CD274, TP53 PI4KA 1415/4885PI4K2B 1823/4885PI4K2A 1623/4885
US-20230310413-A1 PHARMACEUTICAL FORMULATIONS COMPRISING A MALT1 INHIBITOR AND A MIXTURE OF POLYETHYLENE GLYCOL WITH A FATTY ACID MALT1, MGAM, MGLL PI4KA 1557/4885PI4K2B 2209/4885PI4K2A 1799/4885
US-20160289238-A1 HETEROCYCLIC COMPOUNDS AS LSD1 INHIBITORS KDM1B, KDM1A, DOT1L PI4KA 4134/4885PI4K2B 4182/4885PI4K2A 4312/4885
US-20220175760-A1 PHARMACEUTICAL FORMULATIONS TREH, F12, CEL PI4KA 2776/4885PI4K2B 3254/4885PI4K2A 2961/4885
US-11571427-B2 Targeting the CBM signalosome complex induces regulatory T cells to inflame the tumor microenvironment CD47, ICOS, LCK PI4KA 1798/4885PI4K2B 1872/4885PI4K2A 2099/4885
US-10800779-B2 Heterocyclic compounds as LSD1 inhibitors KDM1B, KDM1A, DOT1L PI4KA 4134/4885PI4K2B 4182/4885PI4K2A 4312/4885
US-20070213333-A1 Substituted arylalkanoic acid derivatives and use thereof CYSLTR1, CYSLTR2, LTB4R2 PI4KA 3789/4885PI4K2B 4069/4885PI4K2A 3807/4885
US-20100041725-A1 STABLE PHARMACEUTICAL COMPOSITION SLC5A1, SLC5A2, SLC2A9 PI4KA 4366/4885PI4K2B 3811/4885PI4K2A 3695/4885
US-20180170909-A1 PYRAZOLE DERIVATIVES AS MALT1 INHIBITORS MALT1, PPP3R1, SQSTM1 PI4KA 1711/4885PI4K2B 1587/4885PI4K2A 1834/4885
US-20230414629-A1 MATERIALS AND METHODS OF TREATING CANCER MALT1, TP53, RAD1 PI4KA 1902/4885PI4K2B 2082/4885PI4K2A 2020/4885
US-20210156865-A1 METHODS FOR ASSESSING EFFICACY OF MALT1 INHIBITORS USING AN NF-KB TRANSLOCATION ASSAY NFKBIA, MALT1, NFATC1 PI4KA 3309/4885PI4K2B 3699/4885PI4K2A 3888/4885
US-20090062530-A1 Substituted arylalkanoic acid derivatives and use thereof CYSLTR1, CYSLTR2, LTB4R2 PI4KA 3789/4885PI4K2B 4069/4885PI4K2A 3807/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.