Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8839908 | 0.96 | ALDH1A1 (0.37) | ALDH1A1CYP2C19P2RX7USP2LMNA | |
| SCHEMBL3495245 | 0.79 | CYP2C19 (0.48) | ALDH1A1CYP2C19P2RX7USP2LMNA | |
| SCHEMBL840651 | 0.79 | CYP2C19 (0.48) | ALDH1A1CYP2C19P2RX7USP2LMNA | |
| SCHEMBL3909670 | 0.78 | CYP2C19 (0.47) | ALDH1A1CYP2C19P2RX7USP2LMNA | |
| SCHEMBL5692544 | 0.78 | ALDH1A1 (0.38) | ALDH1A1CYP2C19P2RX7USP2LMNA | |
| SCHEMBL2805815 | 0.77 | CYP2C19 (0.45) | ALDH1A1CYP2C19P2RX7USP2LMNA | |
| SCHEMBL14744077 | 0.75 | MCL1 (0.36) | ALDH1A1CYP2C19P2RX7USP2LMNA | |
| Potassium Ion SCHEMBL4756192 | 0.73 | — | — | |
| SCHEMBL2807409 | 0.72 | HSD11B1 (0.41) | ALDH1A1CYP2C19USP2LMNACYP1A2 | |
| SCHEMBL20724940 | 0.71 | OPRM1 (0.34) | ALDH1A1P2RX7OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693845-A | Cyanocycloalkylacetic acid and ester intermediates for preparing cyclic amino acid anticonvulsant compounds | WARNER-LAMBERT COMPANY (US) | 1997-12-02 | — | — | US | claimed |
| EP-0414262-B1 | Process for the preparation of cyclic amino anticonvulsant compounds | WARNER LAMBERT CO (US) | 1994-11-30 | — | — | EP | claimed |
| US-5132451-A | Process for cyclic amino acid anticonvulsant compounds | WARNER-LAMBERT COMPANY (US) | 1992-07-21 | — | — | US | claimed |
| EP-0414262-A2 | Process for the preparation of cyclic amino anticonvulsant compounds | WARNER-LAMBERT COMPANY (US) | 1991-02-27 | — | — | EP | claimed |
| EP-2024324-A1 | PROCESS FOR PREPARING GABAPENTIN | Pfizer Science and Technology Ireland Limited (IE) | 2009-02-18 | — | — | EP | disclosed |
| WO-2007129286-A1 | PROCESS FOR PREPARING GABAPENTIN | PFIZER SCIENCE AND TECHNOLOGY IRELAND LIMITED (IE) | 2007-11-15 | — | — | WO | disclosed |
| US-5693845-A | Cyanocycloalkylacetic acid and ester intermediates for preparing cyclic amino acid anticonvulsant compounds | WARNER-LAMBERT COMPANY (US) | 1997-12-02 | — | — | US | disclosed |
| EP-0414262-B1 | Process for the preparation of cyclic amino anticonvulsant compounds | WARNER LAMBERT CO (US) | 1994-11-30 | — | — | EP | disclosed |
| US-5362883-A | Process for cyclic amino acid anticonvulsant compounds | WARNER-LAMBERT COMPANY (US) | 1994-11-08 | — | — | US | disclosed |
| US-5319135-A | Process for cyclic amino acid anticonvulsant compounds | WARNER-LAMBERT COMPANY (US) | 1994-06-07 | — | — | US | disclosed |
| US-5132451-A | Process for cyclic amino acid anticonvulsant compounds | WARNER-LAMBERT COMPANY (US) | 1992-07-21 | — | — | US | disclosed |
| EP-0414262-A2 | Process for the preparation of cyclic amino anticonvulsant compounds | WARNER-LAMBERT COMPANY (US) | 1991-02-27 | — | — | EP | disclosed |