Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VCAM1 | P19320 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | PELP1 | Q8IZL8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613558 | 0.89 | VCAM1 (0.40) | VCAM1KMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL13152525 | 0.88 | VCAM1 (0.39) | VCAM1KMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL3118623 | 0.85 | KMT2A (0.49) | VCAM1KMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL28072772 | 0.81 | VCAM1 (0.53) | VCAM1KMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL15139324 | 0.81 | ALDH1A1 (0.41) | KMT2AALDH1A1HPGDNPSR1LMNA | |
| SCHEMBL3836060 | 0.81 | TSHR (0.46) | KMT2AALDH1A1LMNAPDK1MAPT | |
| SCHEMBL3214507 | 0.81 | KDM4E (0.51) | ALDH1A1HPGDNPSR1PKMLMNA | |
| SCHEMBL17204265 | 0.80 | MAPT (0.47) | VCAM1KMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL8474404 | 0.79 | PDK1 (0.65) | VCAM1KMT2AALDH1A1HPGDNPSR1 | |
| SCHEMBL3207172 | 0.78 | S100A4 (0.37) | KMT2AALDH1A1PKMLMNAPDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107208111-B | Compounds and methods for enhancing viral gene transfer to human hematopoietic cells | 蒙特利尔大学 | 2021-07-06 | — | — | CN | disclosed |
| EP-3194602-B1 | COMPOUNDS AND METHODS FOR ENHANCING VIRAL GENE TRANSFER TO HUMAN HEMATOPOIETIC CELLS | UNIV MONTREAL (CA) | 2019-11-06 | — | — | EP | disclosed |
| US-10336747-B2 | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells | Université de Montréal | 2019-07-02 | — | — | US | disclosed |
| EP-2807165-B1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | UNIV MONTREAL (CA) | 2019-05-15 | — | — | EP | disclosed |
| US-10273503-B2 | Compounds and methods for enhancing viral gene transfer to human hematopoietic cells | UNIVERSITE DE MONTREAL (CA) | 2019-04-30 | — | — | US | disclosed |
| US-20180201953-A1 | COMPOUNDS AND METHODS FOR ENHANCING VIRAL GENE TRANSFER TO HUMAN HEMATOPOIETIC CELLS | Université de Montréal (CA) | 2018-07-19 | — | — | US | disclosed |
| US-20170334904-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | Université de Montréal (CA) | 2017-11-23 | — | — | US | disclosed |
| EP-3194602-A1 | COMPOUNDS AND METHODS FOR ENHANCING VIRAL GENE TRANSFER TO HUMAN HEMATOPOIETIC CELLS | Université de Montréal (CA) | 2017-07-26 | — | — | EP | disclosed |
| US-9409906-B2 | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells | UNIVERSITE DE MONTREAL (CA) | 2016-08-09 | — | — | US | disclosed |
| US-20160222017-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | Université de Montréal (CA) | 2016-08-04 | — | — | US | disclosed |
| US-8329907-B2 | Autotaxin inhibitors | MERCK PATENT GMBH (DE) | 2012-12-11 | — | — | US | disclosed |
| US-8193237-B2 | Indole derivative having IκB kinase β inhibitory activity | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2012-06-05 | — | — | US | disclosed |
| US-8193237-B2 | Indole derivative having IκB kinase β inhibitory activity | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2012-06-05 | — | — | US | disclosed |
| EP-2414346-A1 | AUTOTAXIN INHIBITORS | Merck Patent GmbH (DE) | 2012-02-08 | — | — | EP | disclosed |
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRANK TER HAFTUNG (DE) | 2012-01-19 | — | — | US | disclosed |
| WO-2010112124-A1 | AUTOTAXIN INHIBITORS | MERCK PATENT GMBH (DE) | 2010-10-07 | — | — | WO | disclosed |
| US-20100041628-A1 | NOVEL INDOLE DERIVATIVE HAVING IKAPPAB KINASE BETA INHIBITORY ACTIVITY | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2010-02-18 | — | — | US | disclosed |
| US-20100041628-A1 | NOVEL INDOLE DERIVATIVE HAVING IKAPPAB KINASE BETA INHIBITORY ACTIVITY | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2010-02-18 | — | — | US | disclosed |
| EP-2119703-A1 | NOVEL INDOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON I B KINASE | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10273503-B2 | Compounds and methods for enhancing viral gene transfer to human hematopoietic cells | HCLS1, INMT, IDO1 | VCAM1 1205/4885KMT2A 730/4885ALDH1A1 165/4885 |
| US-20120015976-A1 | AUTOTAXIN INHIBITORS | ENPP2, PLA2G12A, LPCAT1 | VCAM1 1389/4885KMT2A 1523/4885ALDH1A1 4088/4885 |
| US-20100041628-A1 | NOVEL INDOLE DERIVATIVE HAVING IKAPPAB KINASE BETA INHIBITORY ACTIVITY | NFKBIA, IKBKB, IKBKG | VCAM1 2238/4885KMT2A 823/4885ALDH1A1 3077/4885 |
| US-20180201953-A1 | COMPOUNDS AND METHODS FOR ENHANCING VIRAL GENE TRANSFER TO HUMAN HEMATOPOIETIC CELLS | HCLS1, INMT, IDO1 | VCAM1 1205/4885KMT2A 730/4885ALDH1A1 165/4885 |
| US-20160222017-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | IDO1, IDO2, INMT | VCAM1 3084/4885KMT2A 772/4885ALDH1A1 47/4885 |
| US-10336747-B2 | Pyrimido[4,5-B]indole derivatives and use thereof in the expansion of hematopoietic stem cells | IDO1, IDO2, INMT | VCAM1 3084/4885KMT2A 772/4885ALDH1A1 47/4885 |
| US-20170334904-A1 | PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS | IDO1, IDO2, INMT | VCAM1 3084/4885KMT2A 772/4885ALDH1A1 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.