Tosylchloramide

Tosylchloramide

SCHEMBL353113

Cc1ccc(S(=O)(=O)NCl)cc1.O.O.O

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Tosylchloramide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP1 known ✓ P03956 1/20 0.59
MMP8 known ✓ P22894 1/20 0.59
MMP13 known ✓ P45452 1/20 0.59
MEN1 known ✓ O00255 2/20 0.53
NOD2 known ✓ Q9HC29 1/20 0.48
GAA P10253 3/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
CA1 P00915 2/20 0.59
CA2 P00918 2/20 0.59
MMP2 P08253 1/20 0.59
MMP9 P14780 1/20 0.59
ALDH1A1 P00352 7/20 0.55
KDM4E B2RXH2 3/20 0.53
HPGD P15428 3/20 0.53
TDP1 Q9NUW8 3/20 0.53
CYP2C9 P11712 3/20 0.53
CYP2C19 P33261 3/20 0.53
KMT2A Q03164 2/20 0.53
CYP1A2 P05177 2/20 0.53
CYP3A4 P08684 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tosylchloramide SCHEMBL2441115 1.00 GAA (0.61) GAASMN1; SMN2CA1CA2MMP1
Tosylchloramide SCHEMBL3615720 0.98 GAA (0.59) GAASMN1; SMN2CA1CA2MMP1
Tosylchloramide SCHEMBL7225596 0.98 GAA (0.59) GAASMN1; SMN2CA1CA2MMP1
Tosylchloramide SCHEMBL6837208 0.98 GAA (0.59) GAASMN1; SMN2CA1CA2MMP1
Tosylchloramide SCHEMBL43534 0.98 GAA (0.64) GAASMN1; SMN2CA1CA2MMP1
Tosylchloramide SCHEMBL5854126 0.98 GAA (0.64) GAASMN1; SMN2CA1CA2MMP1
Tosylchloramide SCHEMBL29424143 0.98 GAA (0.64) GAASMN1; SMN2CA1CA2MMP1
Tosylchloramide SCHEMBL23547495 0.96 GAA (0.57) GAASMN1; SMN2CA1CA2MMP1
Tosylchloramide SCHEMBL2242608 0.95 GAA (0.61) GAASMN1; SMN2CA1CA2MMP1
Tosylchloramide SCHEMBL567565 0.95 GAA (0.61) GAASMN1; SMN2CA1CA2MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 276 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104529993-A Preparation method of medicine micro-molecules containing unsaturated carbonyl UNIV CHANGZHOU 2015-04-22 CN claimed
CN-104524593-A Method for releasing medicines by virtue of ester bond rupture UNIV CHANGZHOU 2015-04-22 CN claimed
CN-101830765-A Method for synthesizing o-halohydrin UNIV FUDAN 2010-09-15 CN claimed
EP-1317460-A4 COMPOUNDS CONTAINING OXAZOLIDINONE MOIETY AND USES THEREOF UNIV COLORADO STATE RES FOUND (US) 2005-04-20 EP claimed
US-20040039209-A1 Compounds containing oxazolidinone moiety and uses thereof NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2004-02-26 US claimed
EP-1317460-A1 COMPOUNDS CONTAINING OXAZOLIDINONE MOIETY AND USES THEREOF COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2003-06-11 EP claimed
WO-2002018391-A1 COMPOUNDS CONTAINING OXAZOLIDINONE MOIETY AND USES THEREOF COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) 2002-03-07 WO claimed
CN-122071464-A Heterocyclic compound, pharmaceutical composition thereof and application thereof 上海璎黎药业有限公司 2026-05-22 CN disclosed
US-12624053-B2 Ras inhibitors Revolution Medicines, Inc. (US) 2026-05-12 US disclosed
US-20260070930-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT 2026-03-12 US disclosed
US-12545683-B2 CBP/catenin signaling pathway inhibitors and uses thereof 3+2 PHARMA, LLC (US) 2026-02-10 US disclosed
US-20260035403-A1 NUCLEOSIDE LINE-1 INHIBITORS TRANSPOSON THERAPEUTICS, INC. (US) 2026-02-05 US disclosed
US-20250388608-A1 RAS INHIBITORS WILMINGTON TRUST, NATIONAL ASSOCIATION, AS AGENT 2025-12-25 US disclosed
EP-0647270-A1 NOVEL MALIGNANT CELL TYPE MARKERS OF THE INTERIOR NUCLEAR MATRIX MATRITECH, INC. (US) 1995-04-12 EP disclosed
US-5403837-A Treating epilepsy, convulsions, schizophrenic and neurological disorders RHONE POULENC RORER S.A. (FR) 1995-04-04 US disclosed
WO-1995007271-A1 SUBSTITUTED OXAZINE AND THIAZINE OXAZOLIDINONE ANTIMICROBIALS THE UPJOHN COMPANY (US) 1995-03-16 WO disclosed
EP-0642668-A1 NUCLEAR MATRIX PROTEIN FLUID ASSAY MATRITECH, INC. (US) 1995-03-15 EP disclosed
WO-1994000573-A1 NOVEL MALIGNANT CELL TYPE MARKERS OF THE INTERIOR NUCLEAR MATRIX MATRITECH, INC. (US) 1994-01-06 WO disclosed
WO-1993009437-A2 NUCLEAR MATRIX PROTEIN FLUID ASSAY MATRITECH, INC. (US) 1993-05-13 WO disclosed
US-4113738-A Conversion of N-tosylsulfoximides to sulfoximines POLAROID CORPORATION (US) 1978-09-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070930-A1 RAS INHIBITORS KRAS, NRAS, RIN1 MMP1 3900/4885MMP8 4408/4885MMP13 4710/4885
US-12624053-B2 Ras inhibitors KRAS, NRAS, HMGCR MMP1 4613/4885MMP8 4194/4885MMP13 4155/4885
US-20260035403-A1 NUCLEOSIDE LINE-1 INHIBITORS L3MBTL1, TDP1, TRDMT1 MMP1 710/4885MMP8 3087/4885MMP13 1924/4885
US-12545683-B2 CBP/catenin signaling pathway inhibitors and uses thereof CREBBP, CREB1, CTNNB1 MMP1 884/4885MMP8 953/4885MMP13 1310/4885
US-20040039209-A1 Compounds containing oxazolidinone moiety and uses thereof OXER1, OXA1L, AOX1 MMP1 4080/4885MMP8 3199/4885MMP13 3703/4885
US-20250388608-A1 RAS INHIBITORS KRAS, NRAS, HMGCR MMP1 4613/4885MMP8 4194/4885MMP13 4155/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.