Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | CENPE | Q02224 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9958598 | 0.92 | CYP2C19 (0.36) | CYP2C19GAAHTTGFERHSP90AA1 | |
| SCHEMBL3574241 | 0.81 | MLYCD (0.35) | CYP2C19GAAHTTGFERCENPE | |
| SCHEMBL9957726 | 0.80 | MLYCD (0.34) | CYP2C19GAAHTTGFERCENPE | |
| SCHEMBL9958596 | 0.79 | MLYCD (0.33) | CYP2C19GAAHTTGFEROPRM1 | |
| SCHEMBL3574238 | 0.78 | MLYCD (0.35) | CYP2C19HSP90AA1OPRM1OPRD1CENPE | |
| SCHEMBL3580029 | 0.77 | MLYCD (0.34) | CYP2C19HSP90AA1OPRM1OPRD1CENPE | |
| SCHEMBL3578664 | 0.77 | CYP2C19 (0.39) | CYP2C19HSP90AA1OPRM1OPRD1CENPE | |
| SCHEMBL3584062 | 0.76 | GBA1 (0.34) | HSP90AA1OPRM1OPRD1CENPETRPV1 | |
| SCHEMBL3576622 | 0.75 | LMNA (0.37) | HSP90AA1OPRM1OPRD1CENPETRPV1 | |
| SCHEMBL1397660 | 0.75 | TRPM8 (0.36) | OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678818-B2 | Anthranilamide and 2-amino-heteroarene-carboxamide compounds | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | claimed |
| EP-1984340-B1 | ANTHRANILAMIDE/2-AMINO-HETEROARENE CARBOXAMIDE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-06-27 | — | — | EP | disclosed |