Sugi Predict

Sugi Predict / Compounds / SCHEMBL3575927

SCHEMBL3575927

SCHEMBL3575927

COc1ccccc1S(=O)(=O)NC(C)(C)C

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ HTR6 P50406 1/20 0.53
▸ KAT6A Q92794 1/20 0.48
▸ NSD2 O96028 2/20 0.47
▸ ACLY P53396 1/20 0.47
▸ SLC40A1 Q9NP59 1/20 0.47
▸ FEN1 P39748 2/20 0.46
▸ ALOX5AP P20292 1/20 0.46
▸ SMN1; SMN2 Q16637 2/20 0.46
▸ SLC22A12 Q96S37 1/20 0.45
▸ NPC1 O15118 2/20 0.44
▸ TSHR P16473 1/20 0.44
▸ ITGAV P06756 1/20 0.44
▸ PKM P14618 1/20 0.44
▸ KDM4E B2RXH2 1/20 0.43
▸ MEN1 O00255 1/20 0.43
▸ LMNA P02545 1/20 0.43
▸ MAPT P10636 1/20 0.43
▸ HPGD P15428 1/20 0.43
▸ RAB9A P51151 1/20 0.43
▸ KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24429431 0.83 NSD2 (0.46) HTR6KAT6ANSD2ACLYFEN1
SCHEMBL18726068 0.83 HTR6 (0.51) HTR6KAT6AACLYSLC40A1SMN1; SMN2
SCHEMBL29352111 0.83 HTR6 (0.51) HTR6KAT6AACLYSLC40A1SMN1; SMN2
SCHEMBL24429401 0.83 PARG (0.48) HTR6KAT6AACLYSLC40A1SMN1; SMN2
SCHEMBL1799288 0.82 NSD2 (0.45) NSD2FEN1ALOX5APSMN1; SMN2NPC1
SCHEMBL2803354 0.82 NSD2 (0.58) NSD2FEN1ALOX5APSMN1; SMN2NPC1
SCHEMBL14680691 0.82 KAT6A (0.49) HTR6KAT6AACLYSLC40A1SLC22A12
SCHEMBL29965203 0.81 L3MBTL1 (0.61) HTR6KAT6AACLYSLC40A1SMN1; SMN2
SCHEMBL2371550 0.81 L3MBTL1 (0.61) HTR6KAT6AACLYSLC40A1SMN1; SMN2
SCHEMBL6735794 0.81 ALPL (0.51) HTR6NSD2SLC40A1SMN1; SMN2SLC22A12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220153734-A1 Pyrazolopyridine Compounds For IRE1 Inhibition Optikira, LLC 2022-05-19 — — US disclosed
US-9139609-B2 C-4″ position substituted macrolide derivative TAISHO PHARMACEUTICAL CO., LTD. (JP) 2015-09-22 — — US disclosed
US-20140046043-A1 C-4\" POSITION SUBSTITUTED MACROLIDE DERIVATIVE MEIJI SEIKA PHARMA CO., LTD. (JP) 2014-02-13 — — US disclosed
US-7855166-B2 Sulfonylamino(thio)carbonyl compounds BAYER CROPSCIENCE GMBH (DE) 2010-12-21 — — US disclosed
US-20100317524-A1 Sulfonylureas BAYER CROPSCIENCE AG (DE) 2010-12-16 — — US disclosed
US-7674810-B2 1,1-dioxo-1H-1Λ6-benzo[d]isothiazol-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one inhibitors of HCV polymerase ROCHE PALO ALTO LLC (US) 2010-03-09 — — US disclosed
CN-101189230-A Heterocyclic antiviral compounds ROCHE PALO ALTO LLC (CH) 2008-05-28 — — CN disclosed
EP-1877386-A1 HERBICIDALLY ACTIVE PHENYLSULPHONYL-UREA Bayer CropScience AG (DE) 2008-01-16 — — EP disclosed
EP-1877380-A1 SULFONYLAMINO(THIO)CARBONYL COMPOUNDS IN THE FORM OF HERBICIDES OR PLANT GROWTH REGULATORS BAYER CROPSCIENCE AG (DE) 2008-01-16 — — EP disclosed
US-20060264329-A1 Sulfonylureas BAYER CROPSCIENCE GMBH (DE) 2006-11-23 — — US disclosed
US-20060258536-A1 Sulfonylamino(thio)carbonyl compounds BAYER CROPSCIENCE GMBH (DE) 2006-11-16 — — US disclosed
US-20060252785-A1 Heterocyclic antiviral compounds ROCHE PALO ALTO LLC 2006-11-09 — — US disclosed
EP-1717228-A1 Sulfonylamino(thio)carbonylderivatives as herbicides or plant growth regulators Bayer CropScience GmbH (DE) 2006-11-02 — — EP disclosed
EP-1717232-A1 Phenylsulfonylureas with herbicidal activity Bayer CropScience GmbH (DE) 2006-11-02 — — EP disclosed
WO-2006114221-A1 SULFONYLAMINO(THIO)CARBONYL COMPOUNDS IN THE FORM OF HERBICIDES OR PLANT GROWTH REGULATORS BAYER CROPSCIENCE AG (DE) 2006-11-02 — — WO disclosed
WO-2006114220-A1 HERBICIDALLY ACTIVE PHENYLSULPHONYL-UREA BAYER CROPSCIENCE AG (DE) 2006-11-02 — — WO disclosed
US-6677277-B1 Substituted sulphonyl amino(thio)carbonyl compounds and their use as herbicides BAYER AKTIENGESELLSCHAFT (DE) 2004-01-13 — — US disclosed
EP-0906293-B1 SUBSTITUTED SULPHONYL AMINO(THIO)CARBONYL COMPOUNDS AND THEIR USE AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2003-09-17 — — EP disclosed
EP-0906293-A1 SUBSTITUTED SULPHONYL AMINO(THIO)CARBONYL COMPOUNDS AND THEIR USE AS HERBICIDES BAYER AG (DE) 1999-04-07 — — EP disclosed
WO-1997046540-A1 SUBSTITUTED SULPHONYL AMINO(THIO)CARBONYL COMPOUNDS AND THEIR USE AS HERBICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-12-11 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100317524-A1 Sulfonylureas IAPP, SLC5A2, SLC5A1 HTR6 3520/4885KAT6A 4719/4885NSD2 3546/4885
US-20060252785-A1 Heterocyclic antiviral compounds EIF2AK2, HAVCR2, POLR2E HTR6 2908/4885KAT6A 1442/4885NSD2 161/4885
US-20060258536-A1 Sulfonylamino(thio)carbonyl compounds TST, CBR3, MYB HTR6 4140/4885KAT6A 2862/4885NSD2 2595/4885
US-20220153734-A1 Pyrazolopyridine Compounds For IRE1 Inhibition XBP1, ERN1, ERN2 HTR6 4676/4885KAT6A 4658/4885NSD2 3784/4885
US-20140046043-A1 C-4\" POSITION SUBSTITUTED MACROLIDE DERIVATIVE MRPL21, MRPS34, MRPL37 HTR6 2658/4885KAT6A 3373/4885NSD2 2039/4885
US-20060264329-A1 Sulfonylureas INSR, FFAR3, GPR119 HTR6 1081/4885KAT6A 2091/4885NSD2 1548/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.