Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL3595933 | 0.97 | ALDH1A1 (0.36) | ALDH1A1MAPK1HTTTYMSIDO1 | |
| SCHEMBL13341660 | 0.78 | ALDH1A1 (0.43) | ALDH1A1MAPK1HTTIDO1MEN1 | |
| SCHEMBL5582661 | 0.78 | CCNA2 (0.46) | ALDH1A1MAPK1HTTIDO1MEN1 | |
| SCHEMBL6210831 | 0.77 | ALDH1A1 (0.45) | ALDH1A1MAPK1HTTIDO1MEN1 | |
| SCHEMBL5457968 | 0.74 | ALDH1A1 (0.38) | ALDH1A1MAPK1HTTIDO1MEN1 | |
| SCHEMBL6776635 | 0.73 | RXFP1 (0.40) | ALDH1A1MAPK1HTTIDO1MEN1 | |
| SCHEMBL6772199 | 0.73 | ALDH1A1 (0.37) | ALDH1A1MAPK1HTTTYMSIDO1 | |
| SCHEMBL30831356 | 0.73 | PNMT (0.56) | ALDH1A1MAPK1HTTIDO1MAPT | |
| SCHEMBL3822440 | 0.73 | PNMT (0.56) | ALDH1A1MAPK1HTTIDO1MAPT | |
| Hydrochloric Acid SCHEMBL20492857 | 0.72 | PNMT (0.55) | ALDH1A1MAPK1HTTIDO1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| US-20240025922-A1 | TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS | MERCK HEALTHCARE KGAA (DE) | 2024-01-25 | — | — | US | disclosed |
| US-20240025922-A1 | TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS | MERCK HEALTHCARE KGAA (DE) | 2024-01-25 | — | — | US | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |
| US-9162983-B2 | Reactivators of organophosphorous inhibited acetylcholinesterase | SOUTHWEST RESEARCH INSTITUTE (US) | 2015-10-20 | — | — | US | disclosed |
| US-9162983-B2 | Reactivators of organophosphorous inhibited acetylcholinesterase | SOUTHWEST RESEARCH INSTITUTE (US) | 2015-10-20 | — | — | US | disclosed |
| US-9162983-B2 | Reactivators of organophosphorous inhibited acetylcholinesterase | SOUTHWEST RESEARCH INSTITUTE (US) | 2015-10-20 | — | — | US | disclosed |
| US-20140350262-A1 | Reactivators Of Organophosphorous Inhibited Acetylcholinesterase | SOUTHWEST RESEARCH INSTITUTE (US) | 2014-11-27 | — | — | US | disclosed |
| US-20140350262-A1 | Reactivators Of Organophosphorous Inhibited Acetylcholinesterase | SOUTHWEST RESEARCH INSTITUTE (US) | 2014-11-27 | — | — | US | disclosed |
| US-20140350262-A1 | Reactivators Of Organophosphorous Inhibited Acetylcholinesterase | SOUTHWEST RESEARCH INSTITUTE (US) | 2014-11-27 | — | — | US | disclosed |
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | RENOVIS, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | RENOVIS, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| EP-1954132-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | Renovis, Inc. (US) | 2008-08-13 | — | — | EP | disclosed |
| US-20070225318-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | BIOLIPOX AB (SE) | 2007-09-27 | — | — | US | disclosed |
| WO-2007100758-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |
| WO-2007100758-A2 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | RENOVIS, INC. (US) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225318-A1 | Pyrazole Compounds Useful In The Treatment Of Inflammation | ALOX15, ALOX15B, ALOX12 | ALDH1A1 306/4885MAPK1 1542/4885HTT 3645/4885 |
| US-20100004222-A1 | Amide Derivatives as Ion-Channel Ligands and Pharmaceutical Compositions and Methods of Using the Same | TRPV1, TRPA1, TRPV2 | ALDH1A1 1265/4885MAPK1 1154/4885HTT 3273/4885 |
| US-20140350262-A1 | Reactivators Of Organophosphorous Inhibited Acetylcholinesterase | ACHE, BCHE, CHAT | ALDH1A1 731/4885MAPK1 4376/4885HTT 3811/4885 |
| US-20240025922-A1 | TETRAHYDROPYRIDO[3,4-d]PYRIMIDINES AS HPK1 INHIBITORS | PDXK, DTYMK, HIPK1 | ALDH1A1 3576/4885MAPK1 404/4885HTT 1429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.