Sugi Predict

Sugi Predict / Compounds / SCHEMBL3586130

SCHEMBL3586130

SCHEMBL3586130

CC(C)(C)OC(=O)NCc1nc(C(=O)O)co1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4A O75164 1/20 0.40
▸ KDM4E B2RXH2 1/20 0.39
▸ LMNA P02545 1/20 0.39
▸ HTT P42858 1/20 0.38
▸ NPSR1 Q6W5P4 1/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ CACNA1H O95180 1/20 0.37
▸ CACNA1B Q00975 1/20 0.37
▸ CACNA1C Q13936 1/20 0.37
▸ CYP1A2 P05177 1/20 0.37
▸ PCSK9 Q8NBP7 1/20 0.37
▸ MEN1 O00255 1/20 0.36
▸ GAA P10253 1/20 0.36
▸ KMT2A Q03164 1/20 0.36
▸ NAMPT P43490 1/20 0.36
▸ GRM2 Q14416 1/20 0.35
▸ BCHE P06276 1/20 0.35
▸ SYK P43405 1/20 0.35
▸ GFER P55789 1/20 0.35
▸ STK17B O94768 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3583656 0.88 KDM4A (0.40) KDM4AKDM4ELMNAHTTNPSR1
SCHEMBL21129147 0.87 HDAC1 (0.39) KDM4AKDM4ELMNAHTTNPSR1
SCHEMBL18764998 0.86 HTT (0.50) KDM4ELMNAHTTNPSR1MEN1
SCHEMBL18078935 0.83 KDM4E (0.40) KDM4AKDM4ELMNAL3MBTL1MEN1
SCHEMBL5013649 0.83 PCSK9 (0.47) HTTNPSR1PCSK9MEN1GAA
SCHEMBL6468245 0.83 KDM4A (0.42) KDM4AKDM4ELMNAHTTNPSR1
SCHEMBL10315062 0.82 KDM4A (0.39) KDM4AKDM4ELMNAHTTL3MBTL1
SCHEMBL7945865 0.81 CNR2 (0.42) KDM4AKDM4ELMNAHTTL3MBTL1
SCHEMBL13342913 0.81 HDAC3 (0.46) KDM4AKDM4E
SCHEMBL3798888 0.81 KDM4A (0.40) KDM4AKDM4ELMNAHTTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3364967-B1 FERROPORTIN INHIBITORS VIFOR INT AG (CH) 2026-05-20 — — EP disclosed
EP-3365339-B1 NOVEL FERROPORTIN INHIBITORS VIFOR INT AG (CH) 2025-07-16 — — EP disclosed
EP-3998260-B1 SGC STIMULATORS CYCLERION THERAPEUTICS INC (US) 2023-11-01 — — EP disclosed
EP-3998260-B1 SGC STIMULATORS CYCLERION THERAPEUTICS INC (US) 2023-11-01 — — EP disclosed
CN-109369635-B Compound or pharmaceutically acceptable salt thereof, application thereof and pharmaceutical composition 赛克里翁治疗有限公司 2023-06-30 — — CN disclosed
US-20230106002-A1 sGC STIMULATORS IRONWOOD PHARMACEUTICALS, INC. 2023-04-06 — — US disclosed
CN-109384778-B Use of a compound or a pharmaceutically acceptable salt thereof for the manufacture of a medicament for the treatment of a disease, health condition or disorder 赛克里翁治疗有限公司 2022-12-13 — — CN disclosed
US-20220363675-A1 Novel Ferroportin Inhibitors VIFOR (INTERNATIONAL) AG (CH) 2022-11-17 — — US disclosed
CN-110016020-B Compound or pharmaceutically acceptable salt thereof, application and pharmaceutical composition thereof 赛克里翁治疗有限公司 2022-07-26 — — CN disclosed
CN-114668761-A Novel ferroportin inhibitors 威佛（国际）股份公司 2022-06-28 — — CN disclosed
CN-101768130-B Derivatives containing aminomethyl-5-membered aromatic heterocycle-4-carboxylic acid, preparation method, drug combination and application thereof TIANJIN INST PHARM RESEARCH 2012-07-04 — — CN disclosed
CN-101768130-A Derivatives containing aminomethyl-5-membered aromatic heterocycle-4-carboxylic acid, preparation method, drug combination and application thereof TIANJIN INST PHARM RESEARCH 2010-07-07 — — CN disclosed
US-20100113305-A1 OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) 2010-05-06 — — US disclosed
US-20080234132-A1 Microcin B17 Analogs And Methods For Their Preparation And Use PLANT BIOSCIENCE LIMITED (GB) 2008-09-25 — — US disclosed
WO-2008009942-A1 HETEROAROMATIC-BASED PEPTIDE MACROCYCLES AS G-QUADRUPLEX LIGANDS CAMBRIDGE ENTERPRISE LTD. (GB) 2008-01-24 — — WO disclosed
US-20060161007-A1 Oxazole and thiazole combinatorial libraries M MARTIN LENORE 2006-07-20 — — US disclosed
EP-1169311-A4 OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES RHODE ISLAND EDUCATION (US) 2004-09-15 — — EP disclosed
EP-1169311-A1 OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES THE BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) 2002-01-09 — — EP disclosed
WO-2000056724-A9 OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES RHODE ISLAND EDUCATION (US) 2001-10-25 — — WO disclosed
WO-2000056724-A1 OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) 2000-09-28 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230106002-A1 sGC STIMULATORS PTGIS, CGAS, GUCY1A1 KDM4A 3973/4885KDM4E 2350/4885LMNA 3314/4885
US-20080234132-A1 Microcin B17 Analogs And Methods For Their Preparation And Use MCM3, MCM7, CCNB3 KDM4A 4209/4885KDM4E 4277/4885LMNA 478/4885
US-20100113305-A1 OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES OXA1L, SPOUT1, BCAT2 KDM4A 3763/4885KDM4E 3386/4885LMNA 4578/4885
US-20060161007-A1 Oxazole and thiazole combinatorial libraries OXA1L, SPOUT1, BCAT2 KDM4A 3763/4885KDM4E 3386/4885LMNA 4578/4885
US-20220363675-A1 Novel Ferroportin Inhibitors HAMP, SLC40A1, HMOX1 KDM4A 4742/4885KDM4E 4503/4885LMNA 2291/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.