Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3586130 | 0.88 | KDM4A (0.40) | KDM4AKDM4ELMNAHTTNPSR1 | |
| SCHEMBL2554277 | 0.87 | HTT (0.49) | KDM4ELMNAHTTNPSR1 | |
| SCHEMBL18078935 | 0.85 | KDM4E (0.40) | KDM4AKDM4ELMNAL3MBTL1HRH3 | |
| SCHEMBL21129147 | 0.83 | HDAC1 (0.39) | KDM4AKDM4ELMNAHTTNPSR1 | |
| SCHEMBL5013656 | 0.83 | PCSK9 (0.46) | DAGLASLC6A2SLC6A4SLC6A3HTT | |
| SCHEMBL7945865 | 0.83 | CNR2 (0.42) | KDM4AKDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL6468245 | 0.82 | KDM4A (0.42) | KDM4AKDM4ELMNAHTTNPSR1 | |
| SCHEMBL6603564 | 0.81 | HDAC3 (0.46) | KDM4AKDM4ELMNA | |
| SCHEMBL10315062 | 0.81 | KDM4A (0.39) | KDM4AKDM4ELMNAHTTL3MBTL1 | |
| SCHEMBL19872891 | 0.81 | KDM4A (0.34) | KDM4AKDM4ELMNAHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11066399-B2 | Ferroportin inhibitors | VIFOR (INTERNATIONAL) AG (CH) | 2021-07-20 | — | — | US | disclosed |
| US-20210139472-A1 | Novel Ferroportin Inhibitors | VIFOR (INTERNATIONAL) AG (CH) | 2021-05-13 | — | — | US | disclosed |
| US-11001579-B2 | Ferroportin inhibitors | VIFOR (INTERNATIONAL) AG (CH) | 2021-05-11 | — | — | US | disclosed |
| US-10738041-B2 | Ferroportin inhibitors | VIFOR (INTERNATIONAL) AG (CH) | 2020-08-11 | — | — | US | disclosed |
| US-10676504-B2 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2020-06-09 | — | — | US | disclosed |
| US-20190345151-A1 | Novel Ferroportin Inhibitors | VIFOR (INTERNATIONAL) AG (CH) | 2019-11-14 | — | — | US | disclosed |
| US-10364239-B2 | Ferroportin inhibitors | VIFOR (INTERNATIONAL) AG (CH) | 2019-07-30 | — | — | US | disclosed |
| EP-3286172-B1 | LSD1 INHIBITORS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2019-06-12 | — | — | EP | disclosed |
| US-20180044376-A1 | Method for Preparing Largazole Analogs and Uses Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-02-15 | — | — | US | disclosed |
| WO-2017068089-A2 | NOVEL FERROPORTIN INHIBITORS | VIFOR (INTERNATIONAL) AG (CH) | 2017-04-27 | — | — | WO | disclosed |
| US-20100029731-A1 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-02-04 | — | — | US | disclosed |
| WO-2010009334-A1 | METHOD FOR PREPARING LARGAZOLE ANALOGS AND USES THEREOF | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2008009942-A1 | HETEROAROMATIC-BASED PEPTIDE MACROCYCLES AS G-QUADRUPLEX LIGANDS | CAMBRIDGE ENTERPRISE LTD. (GB) | 2008-01-24 | — | — | WO | disclosed |
| US-20060252795-A1 | Chemokine receptor binding heterocyclic compounds | GENZYME CORPORATION | 2006-11-09 | — | — | US | disclosed |
| US-7091217-B2 | Chemokine receptor binding heterocyclic compounds | ANORMED, INC. (CA) | 2006-08-15 | — | — | US | disclosed |
| US-20060161007-A1 | Oxazole and thiazole combinatorial libraries | M MARTIN LENORE | 2006-07-20 | — | — | US | disclosed |
| EP-1169311-A4 | OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES | RHODE ISLAND EDUCATION (US) | 2004-09-15 | — | — | EP | disclosed |
| EP-1169311-A1 | OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000056724-A9 | OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES | RHODE ISLAND EDUCATION (US) | 2001-10-25 | — | — | WO | disclosed |
| WO-2000056724-A1 | OXAZOLE AND THIAZOLE COMBINATORIAL LIBRARIES | THE BOARD OF GOVERNORS FOR HIGHER EDUCATION, STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS (US) | 2000-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190345151-A1 | Novel Ferroportin Inhibitors | HAMP, SLC40A1, HMOX1 | KDM4A 4742/4885DAGLA 3083/4885SLC6A2 1420/4885 |
| US-20100029731-A1 | Method for preparing largazole analogs and uses thereof | CYP51A1, ADPRS, LPXN | KDM4A 1717/4885DAGLA 143/4885SLC6A2 4722/4885 |
| US-20210139472-A1 | Novel Ferroportin Inhibitors | HAMP, SLC40A1, HMOX1 | KDM4A 4742/4885DAGLA 3083/4885SLC6A2 1420/4885 |
| US-20060252795-A1 | Chemokine receptor binding heterocyclic compounds | CCR5, CXCR3, CCR2 | KDM4A 4596/4885DAGLA 4172/4885SLC6A2 2731/4885 |
| US-10738041-B2 | Ferroportin inhibitors | SLC40A1, HAMP, TFRC | KDM4A 4847/4885DAGLA 4594/4885SLC6A2 923/4885 |
| US-11066399-B2 | Ferroportin inhibitors | HAMP, SLC40A1, FTH1 | KDM4A 4786/4885DAGLA 3399/4885SLC6A2 1248/4885 |
| US-10676504-B2 | Method for preparing largazole analogs and uses thereof | CYP51A1, ADPRS, LPXN | KDM4A 1717/4885DAGLA 143/4885SLC6A2 4722/4885 |
| US-20060161007-A1 | Oxazole and thiazole combinatorial libraries | OXA1L, SPOUT1, BCAT2 | KDM4A 3763/4885DAGLA 4588/4885SLC6A2 4209/4885 |
| US-11001579-B2 | Ferroportin inhibitors | HAMP, SLC40A1, FTH1 | KDM4A 4786/4885DAGLA 3399/4885SLC6A2 1248/4885 |
| US-10364239-B2 | Ferroportin inhibitors | HAMP, SLC40A1, HMOX1 | KDM4A 4757/4885DAGLA 3393/4885SLC6A2 1131/4885 |
| US-20180044376-A1 | Method for Preparing Largazole Analogs and Uses Thereof | CYP51A1, ADPRS, LPXN | KDM4A 1717/4885DAGLA 143/4885SLC6A2 4722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.