Sugi Predict

Sugi Predict / Compounds / SCHEMBL359701

SCHEMBL359701

SCHEMBL359701

COc1ccc(C)c(NC(C)=O)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.56
▸ GAA P10253 4/20 0.56
▸ ALDH1A1 P00352 3/20 0.56
▸ KDM4E B2RXH2 2/20 0.56
▸ SMN1; SMN2 Q16637 2/20 0.56
▸ NPC1 O15118 1/20 0.56
▸ RAB9A P51151 1/20 0.56
▸ MAPK1 P28482 1/20 0.56
▸ HTT P42858 4/20 0.55
▸ LMNA P02545 2/20 0.55
▸ TSHR P16473 1/20 0.55
▸ EPHX2 P34913 1/20 0.54
▸ HSD17B1 P14061 1/20 0.54
▸ HSD17B2 P37059 1/20 0.54
▸ MEN1 O00255 1/20 0.54
▸ KMT2A Q03164 1/20 0.54
▸ P2RX7 Q99572 1/20 0.53
▸ HPGD P15428 1/20 0.52
▸ MTNR1A P48039 1/20 0.50
▸ MTNR1B P49286 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3704664 0.87 GAA (0.61) MAPTGAAALDH1A1SMN1; SMN2MAPK1
SCHEMBL678961 0.86 RAB9A (0.60) MAPTGAAALDH1A1KDM4ESMN1; SMN2
SCHEMBL29784735 0.86 RAB9A (0.60) MAPTGAAALDH1A1KDM4ESMN1; SMN2
SCHEMBL3657487 0.84 ACHE (0.54) MAPTGAAALDH1A1KDM4ESMN1; SMN2
SCHEMBL2856689 0.82 LMNA (0.55) MAPTALDH1A1KDM4ESMN1; SMN2NPC1
SCHEMBL2502603 0.82 MAPT (0.71) MAPTGAAALDH1A1KDM4ESMN1; SMN2
SCHEMBL4013508 0.81 GAA (0.56) MAPTGAAKDM4ESMN1; SMN2MAPK1
SCHEMBL13741593 0.81 DRD2 (0.51) MAPTGAAALDH1A1KDM4ESMN1; SMN2
SCHEMBL7360829 0.81 HTT (0.54) MAPTGAAALDH1A1KDM4ESMN1; SMN2
SCHEMBL2847925 0.81 ALDH1A1 (0.64) MAPTALDH1A1KDM4ESMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 70 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3971176-A1 AROMATIC AMINE AR AND BET TARGETING PROTEIN DEGRADATION CHIMERA COMPOUND AND USE Hinova Pharmaceuticals Inc. (CN) 2022-03-23 — — EP disclosed
EP-3253749-B1 COMPOUNDS WITH ANTI-TUMORAL ACTIVITY AB SCIENCE (FR) 2021-12-08 — — EP disclosed
EP-3253749-B1 COMPOUNDS WITH ANTI-TUMORAL ACTIVITY AB SCIENCE (FR) 2021-12-08 — — EP disclosed
CN-107531685-B Compounds with antitumor activity AB科学有限公司 2021-04-23 — — CN disclosed
WO-2020233512-A1 AROMATIC AMINE AR AND BET TARGETING PROTEIN DEGRADATION CHIMERA COMPOUND AND USE 成都海创药业有限公司 (CN) 2020-11-26 — — WO disclosed
EP-3053920-B1 COMPOUNDS WITH ANTI-TUMORAL ACTIVITY AB SCIENCE (FR) 2020-04-08 — — EP disclosed
US-10570122-B2 Compounds with anti-tumoral activity AB SCIENCE (FR) 2020-02-25 — — US disclosed
US-10570122-B2 Compounds with anti-tumoral activity AB SCIENCE (FR) 2020-02-25 — — US disclosed
US-20180298026-A1 Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators HOFFMANN-LA ROCHE INC. 2018-10-18 — — US disclosed
US-20180202388-A1 PISTON FOR AN INTERNAL COMBUSTION ENGINE AND METHOD FOR PRODUCING THE PISTON FOR AN INTERNAL COMBUSTION ENGINE FELT PRODUCTS MFG. CO. LLC 2018-07-19 — — US disclosed
WO-2009049113-A1 PIPERIDINYLHYDROXYETHYLPIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTORS GLAXO GROUP LIMITED (GB) 2009-04-16 — — WO disclosed
US-20080262076-A1 Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain JANSSEN PHARMACEUTICA, NV (BE) 2008-10-23 — — US disclosed
US-20080262076-A1 Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain JANSSEN PHARMACEUTICA, NV (BE) 2008-10-23 — — US disclosed
US-5723295-A MULTISTAGE CHEMILUMINESCENT ASSAY WITH PEROXIDASE ENZYME, PH ADJUSTMENT LUMIGEN, INC. (US) 1998-03-03 — — US disclosed
US-5670644-A CHEMILUMINESCENT REACTIONS, PEROXIDASE AND PH FOR IMMUNOASSAY LUMIGEN, INC. (US) 1997-09-23 — — US disclosed
US-5136868-A HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF FMC CORPORATION (US) 1992-08-11 — — US disclosed
EP-0161304-B1 HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF FMC Corporation (US) 1990-01-10 — — EP disclosed
EP-0161304-A4 HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF. FMC CORP (US) 1986-04-15 — — EP disclosed
EP-0161304-A1 HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF. FMC CORP (US) 1985-11-21 — — EP disclosed
WO-1985001939-A1 HERBICIDAL 1-ARYL-4-SUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONES AND SULFUR ANALOGS THEREOF FMC CORPORATION (US) 1985-05-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10570122-B2 Compounds with anti-tumoral activity MKI67, GZMB, RB1 MAPT 4866/4885GAA 601/4885ALDH1A1 311/4885
US-20080262076-A1 Novel Tetracyclic Tetrahydrofuran Derivatives Containing Cyclic Amine Side Chain HTR2C, HTR2A, HTR5A MAPT 3030/4885GAA 2907/4885ALDH1A1 848/4885
US-20180298026-A1 Pyrazolo[1,5a]Pyrimidine Derivatives as IRAK4 Modulators IRAK4, IRAK1, IRAK2 MAPT 1941/4885GAA 4543/4885ALDH1A1 2519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.