Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | SORD | Q00796 | 8/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663850 | 0.76 | SIGMAR1 (0.45) | — | |
| SCHEMBL3627516 | 0.75 | ALDH1A1 (0.42) | ALDH1A1KDM4ELMNASMN1; SMN2USP2 | |
| SCHEMBL3634837 | 0.74 | ALDH1A1 (0.47) | ALDH1A1KDM4EMEN1TSHRKMT2A | |
| SCHEMBL3632727 | 0.73 | ACHE (0.40) | HRH3 | |
| SCHEMBL3633473 | 0.72 | MEN1 (0.48) | MEN1KMT2A | |
| SCHEMBL3632361 | 0.71 | FPR2 (0.46) | HRH3 | |
| SCHEMBL3320791 | 0.71 | HTR1A (0.43) | HRH3ALDH1A1LMNAHTR3ACYP1A2 | |
| SCHEMBL3632513 | 0.70 | CHRM1 (0.40) | ALDH1A1MEN1KMT2A | |
| SCHEMBL3633456 | 0.70 | HRH3 (0.38) | HRH3ALDH1A1HTR3ASORDCYP1A2 | |
| SCHEMBL3628240 | 0.63 | ALDH1A1 (0.34) | HRH3ALDH1A1KDM4EHTR3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155748-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2010-02-24 | — | — | EP | claimed |
| WO-2008144268-A1 | UROTENSIN II RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-11-27 | — | — | WO | claimed |