Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.35 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366107 | 0.88 | MAPT (0.39) | ALDH1A1L3MBTL1MAOBMAPTTDP1 | |
| SCHEMBL364902 | 0.86 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1MAPTKMT2AMEN1 | |
| SCHEMBL365200 | 0.86 | TP53 (0.40) | CASP3SENP8SENP7SENP6ALDH1A1 | |
| SCHEMBL365618 | 0.86 | L3MBTL1 (0.39) | ALDH1A1L3MBTL1MAPTNPC1TDP1 | |
| SCHEMBL365513 | 0.85 | NPC1 (0.40) | ALDH1A1HTTL3MBTL1MAPTNPC1 | |
| SCHEMBL365493 | 0.85 | KMT2A (0.50) | CASP3SENP8SENP7SENP6ALDH1A1 | |
| SCHEMBL367137 | 0.85 | ALOX5 (0.40) | ALDH1A1HTTNR4A2MMP1MMP2 | |
| SCHEMBL365753 | 0.84 | ALDH1A1 (0.35) | ALDH1A1HTTL3MBTL1MAPTTDP1 | |
| SCHEMBL365359 | 0.83 | ALDH1A1 (0.47) | ALDH1A1HTTL3MBTL1MAPTTDP1 | |
| SCHEMBL366794 | 0.83 | PSEN1 (0.36) | ALDH1A1HTTL3MBTL1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |