Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 8/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367707 | 0.89 | EGFR (0.44) | AGTR1EGFRPTGDR2MEN1KMT2A | |
| SCHEMBL365648 | 0.86 | CA9 (0.45) | AGTR1EGFRAKR1C3AKR1C1 | |
| SCHEMBL365826 | 0.85 | KMT2A (0.48) | EGFRKDM4EALDH1A1HPGDMEN1 | |
| SCHEMBL366462 | 0.85 | LMNA (0.46) | AGTR1EGFRKDM4EALDH1A1MEN1 | |
| SCHEMBL365147 | 0.81 | AGTR1 (0.39) | AGTR1EGFRAKR1C3AKR1C1KDM4E | |
| SCHEMBL366133 | 0.80 | AGTR1 (0.41) | AGTR1 | |
| SCHEMBL367746 | 0.78 | EGFR (0.43) | AGTR1EGFRKDM4EALDH1A1MEN1 | |
| SCHEMBL366784 | 0.78 | SCN9A (0.50) | AGTR1EGFR | |
| SCHEMBL365722 | 0.77 | PTGDR2 (0.35) | AGTR1PTGDR2KDM4EALDH1A1MEN1 | |
| SCHEMBL365935 | 0.77 | KDM4E (0.47) | AGTR1EGFRKDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |