Sugi Predict

Sugi Predict / Compounds / SCHEMBL3663477

SCHEMBL3663477

SCHEMBL3663477

O=C(Cl)c1ccc(C(F)(F)F)nc1Cl

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMO Q99835 1/20 0.39
▸ TUBB4A P04350 1/20 0.39
▸ TUBB P07437 1/20 0.39
▸ TUBA3C P0DPH7 1/20 0.39
▸ TUBA1B P68363 1/20 0.39
▸ TUBA4A P68366 1/20 0.39
▸ TUBB4B P68371 1/20 0.39
▸ TUBB3 Q13509 1/20 0.39
▸ TUBB2A Q13885 1/20 0.39
▸ TUBB8 Q3ZCM7 1/20 0.39
▸ TUBA3E Q6PEY2 1/20 0.39
▸ TUBA1A Q71U36 1/20 0.39
▸ TUBA1C Q9BQE3 1/20 0.39
▸ TUBB6 Q9BUF5 1/20 0.39
▸ TUBB2B Q9BVA1 1/20 0.39
▸ TUBB1 Q9H4B7 1/20 0.39
▸ LMNA P02545 1/20 0.38
▸ EGFR P00533 3/20 0.37
▸ GAA P10253 1/20 0.37
▸ P2RX7 Q99572 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30489829 1.00 SMO (0.39) SMOTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL165279 0.85 KEAP1 (0.46) SMOTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL30586206 0.85 KEAP1 (0.46) SMOTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL19616100 0.84 TUBB4A (0.41) SMOTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL30489817 0.84 CASP1 (0.43) SMOTUBB4ATUBBTUBA3CTUBA1B
Hydrochloric Acid SCHEMBL23500735 0.84 KEAP1 (0.44) SMOTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL3453722 0.84 CASP1 (0.43) SMOTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL24198800 0.81 GAA (0.40) SMOTUBB4ATUBBTUBA3CTUBA1B
SCHEMBL192851 0.80 LMNA (0.54) LMNAGAANPC1RAB9A
SCHEMBL1513035 0.80 GLA (0.44) LMNAGAANPC1RAB9ATAS2R14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101959863-A Process for production of 3-amino-2-chloro-6- trifluoromethylpyridine ISHIHARA SANGYO KAISHA 2011-01-26 — — CN claimed
EP-2251329-A1 PROCESS FOR PRODUCTION OF 3-AMINO-2-CHLORO-6- TRIFLUOROMETHYLPYRIDINE ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-11-17 — — EP claimed
US-20260132127-A1 NOVEL SPIRO COMPOUND MITSUBISHI TANABE PHARMA CORPORATION (JP) 2026-05-14 — — US disclosed
US-20240376108-A1 SALT AND CRYSTAL FORM OF PYRAZOLE-CONTAINING POLYCYCLIC DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF JIANGSU HANSOH PHARMACEUTICAL GROUP CO., LTD. (CN) 2024-11-14 — — US disclosed
CN-118894855-A Pyrazole-containing polycyclic derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2024-11-05 — — CN disclosed
CN-118894856-A Pyrazole-containing polycyclic derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2024-11-05 — — CN disclosed
CN-114222746-B Pyrazole-containing polycyclic derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2024-08-02 — — CN disclosed
CN-118176179-A Novel spiro compounds 田边三菱制药株式会社 2024-06-11 — — CN disclosed
EP-4353725-A1 SALT AND CRYSTAL FORM OF PYRAZOLE-CONTAINING POLYCYCLIC DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF Shanghai Hansoh Biomedical Co., Ltd. (CN) 2024-04-17 — — EP disclosed
CN-116406271-A Bicyclic compounds 江苏先声药业有限公司 2023-07-07 — — CN disclosed
WO-2023074847-A1 NOVEL SPIRO COMPOUND 田辺三菱製薬株式会社 2023-05-04 — — WO disclosed
EP-3700890-B1 ALCOXYAMINO DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS ESTEVE PHARMACEUTICALS SA (ES) 2021-11-17 — — EP disclosed
WO-2021115225-A1 PYRAZOLE-CONTAINING POLYCYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海翰森生物医药科技有限公司 2021-06-17 — — WO disclosed
WO-2021115225-A1 PYRAZOLE-CONTAINING POLYCYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF 上海翰森生物医药科技有限公司 2021-06-17 — — WO disclosed
US-20200299297-A1 NEW ALCOXYAMINO DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS ESTEVE PHARMACEUTICALS, S.A. (ES) 2020-09-24 — — US disclosed
EP-3700890-A1 NEW ALCOXYAMINO DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS ESTEVE PHARMACEUTICALS, S.A. (ES) 2020-09-02 — — EP disclosed
CN-111566091-A Novel alkoxyamino derivatives for the treatment of pain and pain related disorders 埃斯特韦制药有限公司 2020-08-21 — — CN disclosed
CN-101959863-A Process for production of 3-amino-2-chloro-6- trifluoromethylpyridine ISHIHARA SANGYO KAISHA 2011-01-26 — — CN disclosed
EP-2251329-A1 PROCESS FOR PRODUCTION OF 3-AMINO-2-CHLORO-6- TRIFLUOROMETHYLPYRIDINE ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-11-17 — — EP disclosed
EP-2251329-A1 PROCESS FOR PRODUCTION OF 3-AMINO-2-CHLORO-6- TRIFLUOROMETHYLPYRIDINE ISHIHARA SANGYO KAISHA, LTD. (JP) 2010-11-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240376108-A1 SALT AND CRYSTAL FORM OF PYRAZOLE-CONTAINING POLYCYCLIC DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF P2RX7, P2RX3, CANX SMO 1772/4885TUBB4A 3005/4885TUBB 3014/4885
US-20200299297-A1 NEW ALCOXYAMINO DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS CACNA1B, CACNB2, CACNA1G SMO 4781/4885TUBB4A 787/4885TUBB 721/4885
US-20260132127-A1 NOVEL SPIRO COMPOUND TRHR, NR3C2, THRB SMO 1578/4885TUBB4A 3140/4885TUBB 2474/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.