Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 5/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670576 | 0.80 | KIF11 (0.47) | ALDH1A1CA2CYP3A4HDAC3HDAC4 | |
| SCHEMBL4929808 | 0.70 | — | — | |
| SCHEMBL4927886 | 0.70 | KIF11 (0.50) | KIF11BCL2CYP1A2 | |
| SCHEMBL3669843 | 0.68 | KIF11 (0.44) | KIF11 | |
| SCHEMBL4927893 | 0.66 | KIF11 (0.39) | KIF11 | |
| SCHEMBL3185224 | 0.65 | CPA3 (0.47) | ALDH1A1CYP3A4HDAC3HDAC4HDAC1 | |
| SCHEMBL3187688 | 0.64 | CPA1 (0.44) | KIF11CYP1A2CYP2D6 | |
| SCHEMBL9016945 | 0.62 | CA2 (0.40) | ALDH1A1CA2CYP3A4HDAC3HDAC4 | |
| SCHEMBL28130399 | 0.62 | MAPT (0.41) | KIF11LMNACHRM2CHRM1CHRM3 | |
| SCHEMBL3185210 | 0.62 | CYP2C19 (0.40) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2695614-B1 | LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS INC (US) | 2017-07-05 | — | — | EP | disclosed |
| US-9150509-B2 | Lipoic acid derivatives | CORNERSTONE PHARMACEUTICALS, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-20140364502-A1 | LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS, INC. | 2014-12-11 | — | — | US | disclosed |
| US-8785475-B2 | Lipoic acid derivatives | CORNERSTONE PHARMACEUTICALS, INC. (US) | 2014-07-22 | — | — | US | disclosed |
| EP-2695614-A1 | Lipoic acid derivatives | Cornerstone Pharmaceuticals, Inc. (US) | 2014-02-12 | — | — | EP | disclosed |
| EP-2139321-B1 | LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS INC (US) | 2013-11-06 | — | — | EP | disclosed |
| EP-2139321-A1 | LIPOIC ACID DERIVATIVES | Cornerstone Pharmaceuticals, Inc. (US) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131117-A1 | LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS, INC. (US) | 2008-10-30 | — | — | WO | disclosed |
| US-20080262034-A1 | selectively kill tumor cells by altering cancer cell metabolism and signal transduction pathways linked to the Warburg Effect; | CORNERSTONE PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364502-A1 | LIPOIC ACID DERIVATIVES | ALOX15, ALOX12, LIPC | ALDH1A1 538/4885CA2 3851/4885CYP3A4 3669/4885 |
| US-20080262034-A1 | selectively kill tumor cells by altering cancer cell metabolism and signal transduction pathways linked to the Warburg Effect; | DLD, SLC25A1, PDK2 | ALDH1A1 745/4885CA2 1715/4885CYP3A4 4260/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.