Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.39 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665671 | 0.79 | KIF11 (0.55) | KIF11RNPEPFOLH1 | |
| SCHEMBL34261 | 0.73 | KIF11 (0.56) | KIF11RNPEPFOLH1 | |
| SCHEMBL342180 | 0.69 | CYP1A2 (0.41) | KIF11FOLH1MME | |
| SCHEMBL856139 | 0.69 | CYP1A2 (0.41) | KIF11FOLH1MME | |
| SCHEMBL3185224 | 0.69 | CPA3 (0.47) | KIF11FOLH1 | |
| SCHEMBL3187688 | 0.69 | CPA1 (0.44) | KIF11MME | |
| SCHEMBL5476409 | 0.69 | RNPEP (0.68) | RNPEPFOLH1 | |
| SCHEMBL19143400 | 0.67 | GRIK1 (0.54) | RNPEPFOLH1MMEGRIK1 | |
| SCHEMBL28130399 | 0.66 | MAPT (0.41) | KIF11MME | |
| SCHEMBL3669845 | 0.66 | ALDH1A1 (0.34) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2695614-B1 | LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS INC (US) | 2017-07-05 | — | — | EP | disclosed |
| US-9150509-B2 | Lipoic acid derivatives | CORNERSTONE PHARMACEUTICALS, INC. (US) | 2015-10-06 | — | — | US | disclosed |
| US-20140364502-A1 | LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS, INC. | 2014-12-11 | — | — | US | disclosed |
| US-8785475-B2 | Lipoic acid derivatives | CORNERSTONE PHARMACEUTICALS, INC. (US) | 2014-07-22 | — | — | US | disclosed |
| EP-2695614-A1 | Lipoic acid derivatives | Cornerstone Pharmaceuticals, Inc. (US) | 2014-02-12 | — | — | EP | disclosed |
| EP-2139321-B1 | LIPOIC ACID DERIVATIVES | CORNERSTONE PHARMACEUTICALS INC (US) | 2013-11-06 | — | — | EP | disclosed |
| US-20080262034-A1 | selectively kill tumor cells by altering cancer cell metabolism and signal transduction pathways linked to the Warburg Effect; | CORNERSTONE PHARMACEUTICALS, INC. | 2008-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140364502-A1 | LIPOIC ACID DERIVATIVES | ALOX15, ALOX12, LIPC | KIF11 4699/4885RNPEP 2080/4885GRM2 3854/4885 |
| US-20080262034-A1 | selectively kill tumor cells by altering cancer cell metabolism and signal transduction pathways linked to the Warburg Effect; | DLD, SLC25A1, PDK2 | KIF11 3871/4885RNPEP 4042/4885GRM2 3216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.