Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | SPR | P35270 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366741 | 0.90 | EGFR (0.38) | AGTR1AKR1C3AKR1C1EGFRHTR2A | |
| SCHEMBL365648 | 0.81 | CA9 (0.45) | AGTR1AKR1C3AKR1C1EGFR | |
| SCHEMBL367747 | 0.81 | AGTR1 (0.48) | AGTR1AKR1C3AKR1C1EGFRKDM4E | |
| SCHEMBL365146 | 0.80 | IDO1 (0.40) | AGTR1AKR1C3EGFRHTR2ASPR | |
| SCHEMBL366462 | 0.78 | LMNA (0.46) | AGTR1EGFRKDM4EALDH1A1MEN1 | |
| SCHEMBL366926 | 0.77 | ALDH1A1 (0.36) | EGFRHTR2AKDM4EALDH1A1HPGD | |
| SCHEMBL366133 | 0.73 | AGTR1 (0.41) | AGTR1 | |
| SCHEMBL365935 | 0.73 | KDM4E (0.47) | AGTR1EGFRKDM4EALDH1A1POLB | |
| SCHEMBL366888 | 0.73 | EGFR (0.44) | AGTR1EGFRKDM4EALDH1A1POLB | |
| SCHEMBL364653 | 0.71 | CA2 (0.43) | AGTR1EGFRHTR2AALDH1A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |