Dimethametryne

Dimethametryne

SCHEMBL367954

CC(N)=O.CCNc1nc(NC(C)C(C)C)nc(SC)n1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HTT P42858 4/20 0.48
LMNA P02545 2/20 0.44
L3MBTL1 Q9Y468 3/20 0.41
MEN1 O00255 1/20 0.41
GAA P10253 1/20 0.41
KMT2A Q03164 1/20 0.41
MCL1 Q07820 1/20 0.41
TSHR P16473 1/20 0.40
ALDH1A1 P00352 2/20 0.40
CYP1A2 P05177 2/20 0.36
CYP2C19 P33261 2/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
MAPT P10636 1/20 0.36
CYP2C9 P11712 1/20 0.36
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethametryne SCHEMBL5183719 0.90 HTT (0.42) HTTLMNAGAATSHRALDH1A1
Dimethametryne SCHEMBL8827486 0.90 HTT (0.42) HTTLMNAGAATSHRALDH1A1
Dimethametryne SCHEMBL67453 0.90 HTT (0.42) HTTLMNAGAATSHRALDH1A1
Dimethametryne SCHEMBL6364817 0.86 HTT (0.49) HTTLMNAL3MBTL1MEN1GAA
Ametryne SCHEMBL23242199 0.78 ALDH1A1 (0.47) HTTLMNAL3MBTL1GAATSHR
Ametryne SCHEMBL65196 0.78 POLB (0.54) HTTLMNAL3MBTL1MEN1GAA
Prometryn SCHEMBL7945620 0.78 POLB (0.54) HTTLMNAL3MBTL1MEN1GAA
Ametryne SCHEMBL8541067 0.78 POLB (0.54) HTTLMNAL3MBTL1MEN1GAA
Prometryn SCHEMBL11160002 0.78 POLB (0.54) HTTLMNAL3MBTL1MEN1GAA
Prometryn SCHEMBL367101 0.78 MAPK1 (0.58) HTTLMNAL3MBTL1MEN1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1531670-B1 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2015-12-09 EP disclosed
US-8551918-B2 Herbicidal composition SYNGENTA CROP PROTECTION LLC (US) 2013-10-08 US disclosed
US-8097561-B2 Herbicidal composition SYNGENTA CROP PROTECTION, INC. (US) 2012-01-17 US disclosed
US-20070197387-A1 Herbicidal Composition SYNGENTA PARTICIPATIONS AG (CH) 2007-08-23 US disclosed
EP-1689227-A2 HERBICIDAL COMPOSITION Syngenta Participations AG (CH) 2006-08-16 EP disclosed
EP-1531670-A4 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2005-11-23 EP disclosed
US-20050233907-A1 Herbicidal composition SYNGENTA CROP PROTECTION AG (CH) 2005-10-20 US disclosed
WO-2005055716-A2 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2005-06-23 WO disclosed
EP-1531670-A1 HERBICIDAL COMPOSITION Syngenta Participations AG (CH) 2005-05-25 EP disclosed
WO-2003105587-A1 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2003-12-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050233907-A1 Herbicidal composition ADH5, ADH1C, AQP3 HTT 348/4885LMNA 3158/4885L3MBTL1 2230/4885
US-20070197387-A1 Herbicidal Composition DDT, HDHD5, DERL1 HTT 525/4885LMNA 2553/4885L3MBTL1 1819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.