Caffeic Acid

Caffeic Acid

SCHEMBL3682144

O=C(O)/C=C\c1ccc(O)c(O)c1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 3/20 1.00
▸ HSD17B10 Q99714 3/20 1.00
▸ CA12 O43570 3/20 1.00
▸ CA1 P00915 3/20 1.00
▸ CA2 P00918 3/20 1.00
▸ CA3 P07451 3/20 1.00
▸ CA4 P22748 3/20 1.00
▸ CA6 P23280 3/20 1.00
▸ CA5A P35218 3/20 1.00
▸ CA7 P43166 3/20 1.00
▸ CA9 Q16790 3/20 1.00
▸ CA14 Q9ULX7 3/20 1.00
▸ CA5B Q9Y2D0 3/20 1.00
▸ MAPT P10636 2/20 1.00
▸ TTR P02766 2/20 1.00
▸ APP P05067 2/20 1.00
▸ AKR1B10 O60218 2/20 1.00
▸ AKR1B1 P15121 2/20 1.00
▸ DPP4 P27487 2/20 1.00
▸ MMP1 P03956 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Caffeic Acid SCHEMBL23359 1.00 KDM4E (1.00) KDM4EHSD17B10CA12CA1CA2
Caffeic Acid SCHEMBL23358 1.00 KDM4E (1.00) KDM4EHSD17B10CA12CA1CA2
Caffeic Acid SCHEMBL29447135 1.00 KDM4E (1.00) KDM4EHSD17B10CA12CA1CA2
Caffeic Acid SCHEMBL30501140 1.00 KDM4E (1.00) KDM4EHSD17B10CA12CA1CA2
Caffeic Acid SCHEMBL7064846 1.00 KDM4E (1.00) KDM4EHSD17B10CA12CA1CA2
Caffeic Acid SCHEMBL30050844 1.00 KDM4E (1.00) KDM4EHSD17B10CA12CA1CA2
Caffeic Acid SCHEMBL1262229 1.00 KDM4E (1.00) KDM4EHSD17B10CA12CA1CA2
Caffeic Acid SCHEMBL29353048 1.00 KDM4E (1.00) KDM4EHSD17B10CA12CA1CA2
Caffeic Acid SCHEMBL21114743 1.00 KDM4E (1.00) KDM4EHSD17B10CA12CA1CA2
Caffeic Acid SCHEMBL9308249 0.98 KDM4E (0.96) KDM4EHSD17B10CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969029-A2 USE OF COSMETICALLY OR DERMATOLOGICALLY SAFE SUBSTITUTED MICHAEL ACCEPTORS FOR THE PREVENTION, REDUCTION OR PROPHYLAXIS OF THE TYROSINASE ACTIVITY OF THE HUMAN SKIN AND/OR THE LIGHTENING OF THE HUMAN SKIN Beiersdorf AG (DE) 2016-01-20 — — EP claimed
CN-105050663-A Use of cosmetically and dermatologically safe substituted michael acceptors to prevent, reduce or prevent human skin tyrosinase activity and/or to lighten skin BEIERSDORF AG 2015-11-11 — — CN claimed
WO-2014139756-A2 USE OF COSMETICALLY OR DERMATOLOGICALLY SAFE SUBSTITUTED MICHAEL ACCEPTORS FOR THE PREVENTION, REDUCTION OR PROPHYLAXIS OF THE TYROSINASE ACTIVITY OF THE HUMAN SKIN AND/OR THE LIGHTENING OF THE HUMAN SKIN BEIERSDORF AG (DE) 2014-09-18 — — WO claimed
CN-103257201-A Method for simultaneous determination of caffeic acid and 8 flavonoids in propolis by using high performance liquid chromatography HANGZHOU BEEWORDS BEE INDUSTRY CO LTD 2013-08-21 — — CN claimed
CN-122080255-A Chitosan-organic acid supermolecule ionic salt and preparation method thereof — 2026-05-26 — — CN disclosed
CN-122038069-A Natural sweet wine low-sulfur brewing method for harvesting white grape after delaying red turning 宁夏大学 2026-05-15 — — CN disclosed
US-20260102359-A1 COMBINATION TREATMENT OF DERMAL AND TRANSDERMAL FIBROTIC DISEASES, DISORDERS AND ASSOCIATED PAIN AND INFLAMMATION ERESINA LLC (US) 2026-04-16 — — US disclosed
US-20260048071-A1 12-LIPOXYGENASE INHIBITORS FOR THE TREATMENT OF LUPUS Cadrenal Therapeutics, Inc. 2026-02-19 — — US disclosed
EP-4615432-A2 12-LIPOXYGENASE INHIBITORS FOR THE TREATMENT OF LUPUS Veralox Therapeutics Inc. (US) 2025-09-17 — — EP disclosed
US-20250255853-A1 HUMAN THERAPEUTIC AGENTS ANKH LIFE SCIENCES LIMITED (IE) 2025-08-14 — — US disclosed
CN-120189402-A A preparation comprising 2 Chinese medicinal materials for treating nonalcoholic fatty liver disease 上海中医药大学附属曙光医院 2025-06-24 — — CN disclosed
CN-116298001-B Vitex negundo particle and detection method and application of fingerprint thereof 上海上药杏灵科技药业股份有限公司 2025-06-13 — — CN disclosed
CN-103257201-A Method for simultaneous determination of caffeic acid and 8 flavonoids in propolis by using high performance liquid chromatography HANGZHOU BEEWORDS BEE INDUSTRY CO LTD 2013-08-21 — — CN disclosed
US-20100203175-A1 DEGLYCATION OF AGEs BASF BEAUTY CARE SOLUTIONS FRANCE S.A.S. (FR) 2010-08-12 — — US disclosed
CN-101765432-A AGE deglycation BASF BEAUTY CARE SOLUTIONS F 2010-06-30 — — CN disclosed
US-20090092975-A1 SELECTABLE MARKER MOLOGIC LTD (GB) 2009-04-09 — — US disclosed
US-20070042026-A1 Prophylactic and therapeutic treatment of topical and transdermal drug-induced skin reactions MORNINGSIDE VENTURE INVESTMENTS LIMITED 2007-02-22 — — US disclosed
EP-0975224-A1 PROCESS AND COMPOSITIONS FOR ENHANCING RELIABILITY OF EXOGENOUS CHEMICAL SUBSTANCES APPLIED TO PLANTS MONSANTO COMPANY (US) 2000-02-02 — — EP disclosed
US-6020287-A USING MIXTURE OF HERBICIDE AND PHENYL-SUBSTITUTED OLEFIN COMPOUND MONSANTO COMPANY (US) 2000-02-01 — — US disclosed
WO-1998033385-A1 PROCESS AND COMPOSITIONS FOR ENHANCING RELIABILITY OF EXOGENOUS CHEMICAL SUBSTANCES APPLIED TO PLANTS MONSANTO COMPANY (US) 1998-08-06 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090092975-A1 SELECTABLE MARKER AMD1, PADI1, PSAT1 KDM4E 3611/4885HSD17B10 193/4885CA12 1162/4885
US-20260048071-A1 12-LIPOXYGENASE INHIBITORS FOR THE TREATMENT OF LUPUS ALOX12, ALOX5, ALOX15 KDM4E 1329/4885HSD17B10 945/4885CA12 3274/4885
US-20260102359-A1 COMBINATION TREATMENT OF DERMAL AND TRANSDERMAL FIBROTIC DISEASES, DISORDERS AND ASSOCIATED PAIN AND INFLAMMATION COL2A1, COLGALT1, PLOD3 KDM4E 2468/4885HSD17B10 1517/4885CA12 1005/4885
US-20250255853-A1 HUMAN THERAPEUTIC AGENTS HASPIN, TIPARP, SHARPIN KDM4E 3824/4885HSD17B10 3242/4885CA12 3777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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