SCHEMBL3697133

SCHEMBL3697133

CC(C)[Si](Oc1ccc(C=O)cc1)(C(C)C)C(C)C

nearest known ligand 0.57

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 1/20 0.57
ALDH1A1 P00352 8/20 0.52
CYP2A6 P11509 3/20 0.52
TYR P14679 1/20 0.47
KDM4E B2RXH2 5/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
LMNA P02545 2/20 0.43
DRD1 P21728 1/20 0.43
CYP2A13 Q16696 1/20 0.42
STS P08842 1/20 0.41
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
KMT2A Q03164 2/20 0.38
MEN1 O00255 1/20 0.38
PARP10 Q53GL7 1/20 0.38
PARP3 Q9Y6F1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13347377 0.94 ALDH1A3 (0.52) ALDH1A3ALDH1A1CYP2A6TYRKDM4E
SCHEMBL13347426 0.94 ALDH1A3 (0.52) ALDH1A3ALDH1A1CYP2A6TYRKDM4E
SCHEMBL190591 0.84 ALDH1A3 (0.44) ALDH1A3ALDH1A1CYP2A6TYRKDM4E
SCHEMBL13347423 0.82 RELA (0.44) ALDH1A3KMT2A
SCHEMBL3791568 0.80 ALDH1A1 (0.44) ALDH1A3ALDH1A1MAPT
SCHEMBL25221171 0.78 SRC (0.47) ALDH1A3ALDH1A1SMN1; SMN2LMNADRD1
SCHEMBL30533425 0.78 SRC (0.47) ALDH1A3ALDH1A1SMN1; SMN2LMNADRD1
SCHEMBL6179860 0.77 SMN1; SMN2 (0.36) ALDH1A3ALDH1A1SMN1; SMN2LMNAMAPT
SCHEMBL3438230 0.77 ALDH1A1 (0.58) ALDH1A3ALDH1A1CYP2A6TYRKDM4E
SCHEMBL2857839 0.76 ALDH1A3 (0.43) ALDH1A3ALDH1A1CYP2A6TYRKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12466784-B2 Analogs of pterostilbene amino acid bearing carbonates for treating a non-alcoholic fatty liver disease and nonalcoholic steatohepatitis APICAL MOLECULAR BIOTECH CO., LTD. (TW) 2025-11-11 US disclosed
EP-4136063-B1 NOVEL ANALOGS OF PTEROSTILBENE AMINO ACID BEARING CARBONATES FOR TREATING A NON-ALCOHOLIC FATTY LIVER DISEASE AND NONALCOHOLIC STEATOHEPATITIS APICAL MOLECULAR BIOTECH CO LTD (TW) 2025-10-22 EP disclosed
US-12370158-B2 Analogs of CYP-eicosanoids for use in treating or preventing a disorder associated with neovascularization and/or inflammation OMEICOS THERAPEUTICS GMBH (DE) 2025-07-29 US disclosed
CN-119868577-A Eribulin drug linker and antibody coupled drug and application thereof 石药集团巨石生物制药有限公司 2025-04-25 CN disclosed
CN-119367342-A CYP-eicosanoids analogs for treating or preventing diseases associated with neovascularization and/or inflammation 奥迈科斯治疗公司 2025-01-28 CN disclosed
EP-3435993-B1 ANALOG OF CYP-EICOSANOIDS FOR USE IN TREATING OR PREVENTING A DISORDER ASSOCIATED WITH NEOVASCULARIZATION AND/OR INFLAMMATION OMEICOS THERAPEUTICS GMBH (DE) 2024-09-25 EP disclosed
US-20230234912-A1 NOVEL ANALOGS OF PTEROSTILBENE AMINO ACID BEARING CARBONATES FOR TREATING A NON-ALCOHOLIC FATTY LIVER DISEASE AND NONALCOHOLIC STEATOHEPATITIS APICAL MOLECULAR BIOTECH CO., LTD. (TW) 2023-07-27 US disclosed
EP-3313816-B1 METABOLICALLY ROBUST ANALOGS OF CYP-EICOSANOIDS FOR THE TREATMENT OF CARDIAC DISEASE OMEICOS THERAPEUTICS GMBH (DE) 2023-05-24 EP disclosed
CN-115835860-A Novel analogues of pterostilbene amino acids with carbonate for the treatment of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis 树顶分子生技股份有限公司 2023-03-21 CN disclosed
EP-4136063-A1 NOVEL ANALOGS OF PTEROSTILBENE AMINO ACID BEARING CARBONATES FOR TREATING A NON-ALCOHOLIC FATTY LIVER DISEASE AND NONALCOHOLIC STEATOHEPATITIS Apical Molecular Biotech. Co., Ltd. (TW) 2023-02-22 EP disclosed
US-20070276138-A1 Modulators of peroxisome proliferator activated receptors BROOKS DAWN A 2007-11-29 US disclosed
US-7192982-B2 Modulators of peroxisome proliferator activated receptors LIGAND PHARMACEUTICALS, INC. (US) 2007-03-20 US disclosed
US-7192982-B2 Modulators of peroxisome proliferator activated receptors LIGAND PHARMACEUTICALS, INC. (US) 2007-03-20 US disclosed
WO-2006128056-A2 NOVEL PHOSPHINIC ACID-CONTAINING THYROMIMETICS METABASIS THERAPEUTICS, INC. (US) 2006-11-30 WO disclosed
US-20060217372-A1 Diaryl ethers as opioid receptor antagonist ELI LILLY AND COMPANY 2006-09-28 US disclosed
EP-1562595-A1 DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 2005-08-17 EP disclosed
US-20050020684-A1 Modulators of peroxisome proliferator activated receptors ELI LILLY AND COMPANY 2005-01-27 US disclosed
WO-2004026305-A1 DIARYL ETHERS AS OPIOID RECEPTOR ANTAGONIST ELI LILLY AND COMPANY (US) 2004-04-01 WO disclosed
EP-1392637-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2004-03-03 EP disclosed
WO-2002100813-A2 MODULATORS OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS ELI LILLY AND COMPANY (US) 2002-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230234912-A1 NOVEL ANALOGS OF PTEROSTILBENE AMINO ACID BEARING CARBONATES FOR TREATING A NON-ALCOHOLIC FATTY LIVER DISEASE AND NONALCOHOLIC STEATOHEPATITIS FABP1, GLS2, SLC1A5 ALDH1A3 2410/4885ALDH1A1 1792/4885CYP2A6 1882/4885
US-12466784-B2 Analogs of pterostilbene amino acid bearing carbonates for treating a non-alcoholic fatty liver disease and nonalcoholic steatohepatitis FABP1, GLS2, SLC1A5 ALDH1A3 2204/4885ALDH1A1 1721/4885CYP2A6 1775/4885
US-20060217372-A1 Diaryl ethers as opioid receptor antagonist OPRM1, OPRL1, OPRD1 ALDH1A3 1999/4885ALDH1A1 2133/4885CYP2A6 503/4885
US-12370158-B2 Analogs of CYP-eicosanoids for use in treating or preventing a disorder associated with neovascularization and/or inflammation ALOX5, ALOX15B, ALOX15 ALDH1A3 126/4885ALDH1A1 274/4885CYP2A6 36/4885
US-20050020684-A1 Modulators of peroxisome proliferator activated receptors NCOA4, PPARG, PPARA ALDH1A3 1372/4885ALDH1A1 2292/4885CYP2A6 181/4885
US-20070276138-A1 Modulators of peroxisome proliferator activated receptors PPARG, NCOA4, PPARA ALDH1A3 1185/4885ALDH1A1 2029/4885CYP2A6 134/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.