Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Fluoride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluoride SCHEMBL1994686 | 1.00 | — | — | |
| Fluoride SCHEMBL27532480 | 0.89 | — | — | |
| Fluoride Ion SCHEMBL1994685 | 0.87 | — | — | |
| Fluoride Ion SCHEMBL27480244 | 0.87 | — | — | |
| Fluoride SCHEMBL17766113 | 0.87 | CA4 (0.33) | — | |
| Fluoride SCHEMBL10382021 | 0.87 | CA4 (0.33) | — | |
| Fluoride SCHEMBL372354 | 0.87 | — | — | |
| Fluoride SCHEMBL29129531 | 0.87 | — | — | |
| Fluoride SCHEMBL10902089 | 0.75 | — | — | |
| Fluoride SCHEMBL6859065 | 0.75 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1235068-B1 | BIOSENSOR | ARKRAY INC (JP) | 2006-01-25 | — | — | EP | claimed |
| US-6916410-B2 | Biosensor | ARKRAY, INC. (JP) | 2005-07-12 | — | — | US | claimed |
| US-20020189941-A1 | Biosensor | ARKRAY, INC. (JP) | 2002-12-19 | — | — | US | claimed |
| EP-1235068-A1 | BIOSENSOR | ARKRAY, Inc. (JP) | 2002-08-28 | — | — | EP | claimed |
| EP-1336839-B1 | Biosensor | ARKRAY INC (JP) | 2012-01-25 | — | — | EP | disclosed |
| EP-1235068-B1 | BIOSENSOR | ARKRAY INC (JP) | 2006-01-25 | — | — | EP | disclosed |
| US-6982027-B2 | Biosensor | ARKRAY, INC. (JP) | 2006-01-03 | — | — | US | disclosed |
| US-6916410-B2 | Biosensor | ARKRAY, INC. (JP) | 2005-07-12 | — | — | US | disclosed |
| US-20040040839-A1 | Biosensor | ARKRAY, INC. (JP) | 2004-03-04 | — | — | US | disclosed |
| EP-1336839-A1 | BIOSENSOR | ARKRAY, Inc. (JP) | 2003-08-20 | — | — | EP | disclosed |
| US-20020189941-A1 | Biosensor | ARKRAY, INC. (JP) | 2002-12-19 | — | — | US | disclosed |
| EP-1235068-A1 | BIOSENSOR | ARKRAY, Inc. (JP) | 2002-08-28 | — | — | EP | disclosed |