Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 9/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.48 |
| ▸ | ME2 | P23368 | 1/20 | 0.47 |
| ▸ | ME1 | P48163 | 1/20 | 0.47 |
| ▸ | ME3 | Q16798 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828404 | 0.96 | OPRM1 (0.52) | L3MBTL1OPRM1PKMTMEM97ME2 | |
| SCHEMBL3860666 | 0.91 | RORC (0.45) | L3MBTL1OPRM1TMEM97ME2ME1 | |
| SCHEMBL3823818 | 0.86 | AGER (0.48) | OPRM1ALDH1A1LMNASMORORC | |
| SCHEMBL3066199 | 0.83 | DRD2 (0.43) | L3MBTL1RAB9ASMN1; SMN2SMORORC | |
| SCHEMBL8179598 | 0.79 | HTR2A (0.57) | L3MBTL1OPRM1ALDH1A1TSHRRAB9A | |
| SCHEMBL4737202 | 0.79 | SLC6A9 (0.43) | L3MBTL1ALDH1A1TSHRSMO | |
| SCHEMBL3827281 | 0.78 | AGER (0.54) | L3MBTL1ME2ME1ME3RAB9A | |
| SCHEMBL4739773 | 0.78 | SLC6A9 (0.45) | L3MBTL1ALDH1A1TSHRSMO | |
| SCHEMBL3829302 | 0.78 | ALDH1A1 (0.50) | OPRM1TMEM97ME2ME1ME3 | |
| SCHEMBL3827832 | 0.77 | AGER (0.53) | L3MBTL1TMEM97ME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | disclosed |