Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | ME2 | P23368 | 1/20 | 0.44 |
| ▸ | ME1 | P48163 | 1/20 | 0.44 |
| ▸ | ME3 | Q16798 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 2/20 | 0.44 |
| ▸ | FNTB | P49356 | 2/20 | 0.44 |
| ▸ | SMO | Q99835 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3824036 | 0.91 | L3MBTL1 (0.55) | RORCME2ME1ME3SMO | |
| SCHEMBL3823818 | 0.87 | AGER (0.48) | RORCSMOOPRM1LMNAHTR2A | |
| SCHEMBL3828404 | 0.87 | OPRM1 (0.52) | RORCME2ME1ME3OPRM1 | |
| SCHEMBL3066199 | 0.84 | DRD2 (0.43) | RORCSMOL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL8179598 | 0.80 | HTR2A (0.57) | OPRM1L3MBTL1HTR2AMEN1KMT2A | |
| SCHEMBL4737202 | 0.80 | SLC6A9 (0.43) | SMOL3MBTL1HTR2AKMT2AKDM4E | |
| SCHEMBL3827281 | 0.79 | AGER (0.54) | ME2ME1ME3L3MBTL1HTR2A | |
| SCHEMBL4739773 | 0.79 | SLC6A9 (0.45) | SMOL3MBTL1HTR2AKMT2AKDM4E | |
| SCHEMBL3827832 | 0.78 | AGER (0.53) | ME2ME1ME3L3MBTL1SIGMAR1 | |
| SCHEMBL20780538 | 0.78 | OPRM1 (0.62) | OPRM1LMNAHTR2ATMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097379-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | Wyeth a Corporation of the State of Delaware (US) | 2009-09-09 | — | — | EP | claimed |
| WO-2008073936-A1 | CARBOXAMIDE DERIVATIVES AS ION CHANNEL MODULATORS | WYETH (US) | 2008-06-19 | — | — | WO | claimed |