Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | SRD5A1 | P18405 | 6/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1701852 | 0.92 | CYP2A6 (0.54) | CYP2A6METAP1SRD5A1PARP10PARP11 | |
| SCHEMBL5146565 | 0.88 | METAP1 (0.44) | CYP2A6METAP1PARP10PARP11PARP1 | |
| SCHEMBL17037968 | 0.88 | METAP1 (0.44) | CYP2A6METAP1SRD5A1PARP10PARP11 | |
| SCHEMBL10177007 | 0.87 | METAP1 (0.46) | CYP2A6METAP1SRD5A1PARP10PARP11 | |
| SCHEMBL6584911 | 0.85 | METAP1 (0.52) | CYP2A6METAP1PARP10PARP11PARP1 | |
| SCHEMBL6905898 | 0.84 | ALDH1A1 (0.47) | CYP2A6METAP1SRD5A1PARP10PARP11 | |
| SCHEMBL27844103 | 0.81 | CYP2A6 (0.46) | CYP2A6METAP1SRD5A1PARP10PARP11 | |
| SCHEMBL27861246 | 0.81 | CYP2A6 (0.46) | CYP2A6METAP1SRD5A1PARP10PARP11 | |
| SCHEMBL12430501 | 0.80 | METAP1 (0.44) | CYP2A6METAP1PARP10PARP11PARP1 | |
| SCHEMBL5929505 | 0.78 | CYP2A6 (0.58) | CYP2A6METAP1PARP10PARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227472-A1 | FUSED PYRIDONE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI JEMINCARE PHARMACEUTICALS CO., LTD (CN) | 2023-07-20 | — | — | US | disclosed |
| US-20230128402-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | THE TRUSTEES OF PRINCETON UNIVERSITY | 2023-04-27 | — | — | US | disclosed |
| US-20180127374-A1 | BENZOMORPHAN COMPOUNDS AS OPIOID RECEPTORS MODULATORS | PURDUE PHARMA LP (US) | 2018-05-10 | — | — | US | disclosed |
| WO-2018068357-A1 | NOVEL SIRT2 PROTEIN INHIBITOR AND PHARMACEUTICAL USE THEREOF | 西华大学 | 2018-04-19 | — | — | WO | disclosed |
| US-20170290816-A1 | BENZOMORPHAN ANALOGS AND THE USE THEREOF | PURDUE PHARMA L.P. (US) | 2017-10-12 | — | — | US | disclosed |
| EP-2860176-B1 | HETEROCYCLIC GROUP CONTAINED AMINO-METHANOL DERIVATIVE, AND SALT, SYNTHETIC METHOD AND USE THEREOF | BEIJING FORELAND BIOPHARMA CO LTD (CN) | 2017-09-27 | — | — | EP | disclosed |
| US-20150210646-A1 | BENZOMORPHAN COMPOUNDS AS OPIOID RECEPTORS MODULATORS | PURDUE PHARMA L.P. | 2015-07-30 | — | — | US | disclosed |
| US-8524738-B2 | Quinolinones and quinoxalinones as antibacterial composition | TOYAMA CHEMICAL CO., LTD. (JP) | 2013-09-03 | — | — | US | disclosed |
| US-8436016-B2 | Fused heterocyclic M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. | 2013-05-07 | — | — | US | disclosed |
| US-20120214990-A1 | QUINOLINONES AND QUINOXALINONES AS ANTIBACTERIAL COMPOSITION | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2012-08-23 | — | — | US | disclosed |
| US-20070225528-A1 | Process for Producing Optically Active Alcohol | NAGOYA INDUSTRIAL SCIENCE RESEARCH CENTER (JP) | 2007-09-27 | — | — | US | disclosed |
| CN-101018766-A | Process for preparing substituted tetralin and substituted indane derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2007-08-15 | — | — | CN | disclosed |
| EP-1745016-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRALIN AND SUBSTITUTED INDANE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-24 | — | — | EP | disclosed |
| EP-1741693-A1 | PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE ALCOHOLS | Nagoya Industrial Science Research Institute (JP) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005105737-A1 | PROCESS FOR THE PREPARATION OF SUBSTITUTED TETRALIN AND SUBSTITUTED INDANE DERIVATIVES | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-11-10 | — | — | WO | disclosed |
| US-20050240049-A1 | Process for the preparation of substituted tetralin and substituted indane derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-10-27 | — | — | US | disclosed |
| EP-0535034-B1 | PHARMACEUTICALLY ACTIVE BENZOQUINAZOLINE COMPOUNDS | WELLCOME FOUND (GB) | 2002-08-14 | — | — | EP | disclosed |
| EP-0635497-B1 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compostions containing them | ADIR (FR) | 1998-05-20 | — | — | EP | disclosed |
| US-5436261-A | Adrenergic agonists | ADIR ET COMPAGNIE (FR) | 1995-07-25 | — | — | US | disclosed |
| EP-0635497-A2 | Benzospiroalkene derivatives, process for their preparation and pharmaceutical compostions containing them | ADIR ET COMPAGNIE (FR) | 1995-01-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225528-A1 | Process for Producing Optically Active Alcohol | ADH1C, ADH1A, ADH5 | CYP2A6 1034/4885METAP1 4453/4885SRD5A1 19/4885 |
| US-20150210646-A1 | BENZOMORPHAN COMPOUNDS AS OPIOID RECEPTORS MODULATORS | OPRL1, OPRM1, OPRD1 | CYP2A6 555/4885METAP1 1477/4885SRD5A1 693/4885 |
| US-20180127374-A1 | BENZOMORPHAN COMPOUNDS AS OPIOID RECEPTORS MODULATORS | OPRL1, OPRM1, OPRD1 | CYP2A6 555/4885METAP1 1477/4885SRD5A1 693/4885 |
| US-20230227472-A1 | FUSED PYRIDONE COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | KRAS, NRAS, WEE1 | CYP2A6 607/4885METAP1 2788/4885SRD5A1 1485/4885 |
| US-20120214990-A1 | QUINOLINONES AND QUINOXALINONES AS ANTIBACTERIAL COMPOSITION | NQO2, ASNS, NDUFS1 | CYP2A6 1680/4885METAP1 3082/4885SRD5A1 3429/4885 |
| US-20170290816-A1 | BENZOMORPHAN ANALOGS AND THE USE THEREOF | OPRL1, OPRK1, OPRD1 | CYP2A6 173/4885METAP1 3392/4885SRD5A1 739/4885 |
| US-20050240049-A1 | Process for the preparation of substituted tetralin and substituted indane derivatives | TDO2, TTI2, ITPA | CYP2A6 973/4885METAP1 2595/4885SRD5A1 1611/4885 |
| US-20230128402-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | PAH, ALDH2, IDH2 | CYP2A6 1025/4885METAP1 1926/4885SRD5A1 478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.