Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | TLR2 | O60603 | 1/20 | 0.41 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | FABP7 | O15540 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL6026967 | 0.96 | KMT2A (0.58) | KMT2AEPHX2DOT1LTLR2TLR1 | |
| SCHEMBL260592 | 0.88 | KMT2A (0.69) | KMT2AEPHX2DOT1LOPRD1FABP7 | |
| Sulfuric Acid SCHEMBL3444552 | 0.87 | KMT2A (0.61) | KMT2AEPHX2DOT1LOPRD1CASP3 | |
| Sulfuric Acid SCHEMBL3444555 | 0.87 | KMT2A (0.61) | KMT2AEPHX2DOT1LOPRD1CASP3 | |
| SCHEMBL19450607 | 0.81 | KMT2A (0.64) | KMT2AEPHX2OPRD1FABP7FABP5 | |
| SCHEMBL230688 | 0.81 | KMT2A (0.72) | KMT2AEPHX2DOT1LFABP7FABP5 | |
| SCHEMBL31031901 | 0.81 | KMT2A (0.72) | KMT2AEPHX2DOT1LFABP7FABP5 | |
| SCHEMBL29468684 | 0.81 | KMT2A (0.72) | KMT2AEPHX2DOT1LFABP7FABP5 | |
| Potassium Ion SCHEMBL17079658 | 0.81 | KMT2A (0.62) | KMT2AEPHX2TLR2TLR1OPRD1 | |
| SCHEMBL793384 | 0.81 | KMT2A (0.85) | KMT2AEPHX2TLR2TLR1FABP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4169944-A1 | PROCESS FOR PREPARING HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE | Biomolecular Holdings LLC (US) | 2023-04-26 | — | — | EP | disclosed |
| US-11572398-B2 | GLP-1 derivatives and uses thereof | NOVO NORDISK A/S (DK) | 2023-02-07 | — | — | US | disclosed |
| US-20220275108-A1 | HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE | BIOMOLECULAR HOLDINGS LLC (US) | 2022-09-01 | — | — | US | disclosed |
| EP-3701971-B1 | COMPOUNDS USEFUL IN PREPARING HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE | BIOMOLECULAR HOLDINGS LLC (US) | 2022-07-06 | — | — | EP | disclosed |
| US-11220556-B2 | Hybrid immunoglobulin containing non-peptidyl linkage | BIOMOLECULAR HOLDINGS LLC (US) | 2022-01-11 | — | — | US | disclosed |
| EP-3611180-B1 | HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE | BIOMOLECULAR HOLDINGS LLC (US) | 2021-12-22 | — | — | EP | disclosed |
| US-20210340222-A1 | HYBRID IMMUNOGLOBULIN CONTAINING NONPEPTIDYL LINKAGE | BIOMOLECULAR HOLDINGS LLC (US) | 2021-11-04 | — | — | US | disclosed |
| US-11066459-B2 | Hybrid immunoglobulin containing non-peptidyl linkage | BIOMOLECULAR HOLDINGS LLC (US) | 2021-07-20 | — | — | US | disclosed |
| EP-3701971-A1 | COMPOUNDS USEFUL IN PREPARING HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE | Capon, Daniel J. (US) | 2020-09-02 | — | — | EP | disclosed |
| EP-3611180-A1 | HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE | Capon, Daniel J. (US) | 2020-02-19 | — | — | EP | disclosed |
| US-20170320927-A1 | GLP-1 Derivatives and Uses Thereof | NOVO NORDISK A/S (DK) | 2017-11-09 | — | — | US | disclosed |
| EP-3226906-A1 | GLP-1 DERIVATIVES AND USES THEREOF | Novo Nordisk A/S (DK) | 2017-10-11 | — | — | EP | disclosed |
| US-20170008950-A1 | HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE | BIOMOLECULAR HOLDINGS LLC | 2017-01-12 | — | — | US | disclosed |
| WO-2016083499-A1 | GLP-1 DERIVATIVES AND USES THEREOF | NOVO NORDISK A/S (DK) | 2016-06-02 | — | — | WO | disclosed |
| US-9012603-B2 | Peptides that block the binding of IgG to FcRn | BIOGEN IDEC HEMOPHILIA INC. (US) | 2015-04-21 | — | — | US | disclosed |
| US-8906844-B2 | Immunomodulatory peptides | BIOGEN IDEC HEMOPHILIA INC. (US) | 2014-12-09 | — | — | US | disclosed |
| US-8101186-B2 | Peptides that block the binding of IgG to FcRn | SYNTONIX PHARMACEUTICALS, INC. (US) | 2012-01-24 | — | — | US | disclosed |
| US-20110230639-A1 | IMMUNOMODULATORY PEPTIDES | SYNTONIX PHARMACEUTICALS INC. (US) | 2011-09-22 | — | — | US | disclosed |
| US-20110059889-A1 | PEPTIDES THAT BLOCK THE BINDING OF IgG TO FcRn | SYNTONIX PHARMACEUTICALS, INC. | 2011-03-10 | — | — | US | disclosed |
| US-20070254831-A1 | PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn | BIOGEN HEMOPHILIA INC. | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11066459-B2 | Hybrid immunoglobulin containing non-peptidyl linkage | FCGR3B, FCGR2A, SCLY | KMT2A 3227/4885EPHX2 667/4885DOT1L 3720/4885 |
| US-20220275108-A1 | HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE | FCGR3B, FCGR2A, VSIG8 | KMT2A 2199/4885EPHX2 388/4885DOT1L 2654/4885 |
| US-11220556-B2 | Hybrid immunoglobulin containing non-peptidyl linkage | FCGR3B, FCGR2A, VSIG8 | KMT2A 1597/4885EPHX2 457/4885DOT1L 1380/4885 |
| US-20110059889-A1 | PEPTIDES THAT BLOCK THE BINDING OF IgG TO FcRn | FCGRT, FCGR3B, FCGR1A | KMT2A 4447/4885EPHX2 3220/4885DOT1L 4853/4885 |
| US-20210340222-A1 | HYBRID IMMUNOGLOBULIN CONTAINING NONPEPTIDYL LINKAGE | FCGR3B, FCGR2A, SCLY | KMT2A 3177/4885EPHX2 559/4885DOT1L 3719/4885 |
| US-11572398-B2 | GLP-1 derivatives and uses thereof | GLP1R, GIPR, GCG | KMT2A 4053/4885EPHX2 1828/4885DOT1L 4665/4885 |
| US-20070254831-A1 | PEPTIDES THAT BLOCK THE BINDING OF IgG to FcRn | FCGRT, FCGR3B, FCGR1A | KMT2A 4447/4885EPHX2 3220/4885DOT1L 4853/4885 |
| US-20170320927-A1 | GLP-1 Derivatives and Uses Thereof | GLP1R, GIPR, GCG | KMT2A 4053/4885EPHX2 1828/4885DOT1L 4665/4885 |
| US-20170008950-A1 | HYBRID IMMUNOGLOBULIN CONTAINING NON-PEPTIDYL LINKAGE | FCGR3B, SCLY, FCGR2A | KMT2A 2998/4885EPHX2 766/4885DOT1L 3394/4885 |
| US-20110230639-A1 | IMMUNOMODULATORY PEPTIDES | FCGRT, FCGR3B, FCGR2A | KMT2A 2817/4885EPHX2 2888/4885DOT1L 2483/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.