Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073210 | 0.80 | CYP3A4 (0.46) | OPRM1OPRD1OPRK1NPC1RAB9A | |
| SCHEMBL20791731 | 0.80 | OPRM1 (0.54) | OPRM1OPRD1OPRK1SLC1A3SLC1A2 | |
| SCHEMBL1273081 | 0.80 | CYP3A4 (0.46) | OPRM1OPRD1OPRK1NPC1RAB9A | |
| SCHEMBL27661235 | 0.79 | OPRM1 (0.39) | OPRM1OPRD1OPRK1SLC1A3SLC1A2 | |
| SCHEMBL4594149 | 0.77 | RAB9A (0.43) | NPC1RAB9ATDP1KMT2AMEN1 | |
| SCHEMBL4773478 | 0.77 | LMNA (0.41) | OPRM1OPRD1NPC1RAB9AMME | |
| SCHEMBL10806221 | 0.75 | OPRM1 (0.42) | OPRM1OPRD1OPRK1SLC1A3SLC1A2 | |
| SCHEMBL4583741 | 0.74 | MMP1 (0.43) | NPC1RAB9AKMT2AMEN1POLB | |
| SCHEMBL3722221 | 0.73 | RIPK1 (0.40) | TDP1CYP1A2POLBHTT | |
| SCHEMBL4379160 | 0.72 | FDPS (0.46) | CYP1A2CYP2C9CYP2C19HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032653-A1 | INHIBITORS OF AKT ACTIVITY | SMITH KLINE BEECHAM CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |