Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | BCL9 | O00512 | 1/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA1 | P00915 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.45 |
| ▸ | CA4 | P22748 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3912666 | 0.99 | HTR2A (0.50) | HTR2ABCL9CTNNB1GAAMAPT | |
| SCHEMBL22959846 | 0.91 | HTR2A (0.56) | HTR2ABCL9CTNNB1GAAMAPT | |
| SCHEMBL10062012 | 0.91 | HTR2A (0.56) | HTR2ABCL9CTNNB1GAAMAPT | |
| SCHEMBL763025 | 0.90 | HTR2A (0.57) | HTR2ABCL9CTNNB1GAAMAPT | |
| SCHEMBL1037616 | 0.87 | HTR2A (0.50) | HTR2ABCL9CTNNB1GAAMAPT | |
| SCHEMBL11998880 | 0.87 | HTR2A (0.52) | HTR2ABCL9CTNNB1GAAMAPT | |
| SCHEMBL409598 | 0.86 | HTR2A (0.59) | HTR2ABCL9CTNNB1GAAMAPT | |
| SCHEMBL14876975 | 0.86 | HTR2A (0.54) | HTR2ABCL9CTNNB1GAAMAPT | |
| SCHEMBL1958366 | 0.86 | MGLL (0.60) | HTR2ABCL9CTNNB1GAAMAPT | |
| SCHEMBL21097370 | 0.86 | HTR2A (0.51) | HTR2ABCL9CTNNB1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274279-B1 | NITRIC OXIDE DONATING PROSTAMIDES | NICOX SA (FR) | 2013-07-31 | — | — | EP | disclosed |
| US-8101658-B2 | Nitric oxide donating prostamides | NICOX S.A. (FR) | 2012-01-24 | — | — | US | disclosed |
| US-8101658-B2 | Nitric oxide donating prostamides | NICOX S.A. (FR) | 2012-01-24 | — | — | US | disclosed |
| EP-2021324-B1 | NITRATED HETEROCYCLIC COMPOUNDS AS ENDOTHELIN RECEPTOR ANTAGONIST | NICOX SA (FR) | 2011-12-14 | — | — | EP | disclosed |
| US-20110092590-A1 | NITRIC OXIDE DONATING PROSTAMIDES | NICOX S.A. (FR) | 2011-04-21 | — | — | US | disclosed |
| US-20110092590-A1 | NITRIC OXIDE DONATING PROSTAMIDES | NICOX S.A. (FR) | 2011-04-21 | — | — | US | disclosed |
| EP-2274279-A1 | NITRIC OXIDE DONATING PROSTAMIDES | Nicox S.A. (FR) | 2011-01-19 | — | — | EP | disclosed |
| US-20090325947-A1 | NITRATE ESTERS OF PIPERIDINES | NOVARTIS AG (CH) | 2009-12-31 | — | — | US | disclosed |
| US-20090318432-A1 | Nitrate esters of aminoalcohols | SPEEDEL EXPERIMENTA AG (CH) | 2009-12-24 | — | — | US | disclosed |
| WO-2009136281-A1 | NITRIC OXIDE DONATING PROSTAMIDES | NICOX S.A. (FR) | 2009-11-12 | — | — | WO | disclosed |
| US-20090263472-A1 | ENDOTHELIN RECEPTOR ANTAGONIST DERIVATIVES | NICOX S.A. (FR) | 2009-10-22 | — | — | US | disclosed |
| EP-2061751-A1 | NITRATE ESTERS OF AMINOALCOHOLS | Novartis Ag (CH) | 2009-05-27 | — | — | EP | disclosed |
| EP-2049514-A1 | NITRATE ESTERS OF PIPERIDINES | Speedel Experimenta AG (CH) | 2009-04-22 | — | — | EP | disclosed |
| US-20080274171-A1 | Renin Inhibitors Nitroderivatives | NICOX S.A. (FR) | 2008-11-06 | — | — | US | disclosed |
| EP-1934186-A2 | RENIN INHIBITORS NITRODERIVATIVES | NicOx S.A. (FR) | 2008-06-25 | — | — | EP | disclosed |
| WO-2008031811-A1 | NITRATE ESTERS OF AMINOALCOHOLS | SPEEDEL EXPERIMENTA AG (CH) | 2008-03-20 | — | — | WO | disclosed |
| WO-2008017685-A1 | NITRATE ESTERS OF PIPERIDINES | SPEEDEL EXPERIMENTA AG (CH) | 2008-02-14 | — | — | WO | disclosed |
| WO-2007045551-A2 | RENIN INHIBITORS NITRODERIVATIVES | NICOX S.A. (FR) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090263472-A1 | ENDOTHELIN RECEPTOR ANTAGONIST DERIVATIVES | EDNRA, EDNRB, ECE1 | HTR2A 456/4885BCL9 3737/4885CTNNB1 2996/4885 |
| US-20110092590-A1 | NITRIC OXIDE DONATING PROSTAMIDES | PTGIS, PTGIR, NOS2 | HTR2A 1389/4885BCL9 2183/4885CTNNB1 4327/4885 |
| US-20090318432-A1 | Nitrate esters of aminoalcohols | NOS2, NOS1, NOS3 | HTR2A 3879/4885BCL9 4314/4885CTNNB1 4521/4885 |
| US-20090325947-A1 | NITRATE ESTERS OF PIPERIDINES | NOS2, NOS1, NOS3 | HTR2A 2234/4885BCL9 2967/4885CTNNB1 4877/4885 |
| US-20080274171-A1 | Renin Inhibitors Nitroderivatives | REN, AGTR1, ACE | HTR2A 1843/4885BCL9 4506/4885CTNNB1 466/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.