SCHEMBL4003605

SCHEMBL4003605

COc1cc(NC(=O)CCl)cc(OC)c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.71
POLB P06746 2/20 0.71
L3MBTL1 Q9Y468 1/20 0.59
MEN1 O00255 6/20 0.56
TSHR P16473 1/20 0.56
KDM4E B2RXH2 2/20 0.55
MAPT P10636 1/20 0.55
ALDH1A1 P00352 4/20 0.54
NPC1 O15118 2/20 0.53
RAB9A P51151 2/20 0.53
SMN1; SMN2 Q16637 2/20 0.53
TP53 P04637 1/20 0.53
CYP1A2 P05177 1/20 0.53
CYP3A4 P08684 1/20 0.53
GAA P10253 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
CYP2C19 P33261 1/20 0.53
HTT P42858 2/20 0.51
MITF O75030 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24667605 0.90 KMT2A (0.58) KMT2APOLBL3MBTL1MEN1TSHR
SCHEMBL9594973 0.89 KMT2A (0.57) KMT2APOLBL3MBTL1MEN1TSHR
SCHEMBL31703165 0.88 KMT2A (0.56) KMT2APOLBL3MBTL1MEN1TSHR
SCHEMBL14468583 0.83 KMT2A (1.00) KMT2APOLBL3MBTL1MEN1TSHR
SCHEMBL1837650 0.83 ALDH1A1 (0.70) KMT2APOLBL3MBTL1MEN1TSHR
SCHEMBL31390722 0.83 ALDH1A1 (0.70) KMT2APOLBL3MBTL1MEN1TSHR
SCHEMBL1289638 0.81 L3MBTL1 (0.69) KMT2AL3MBTL1MEN1KDM4EMAPT
SCHEMBL7904920 0.81 KMT2A (0.71) KMT2APOLBL3MBTL1MEN1TSHR
SCHEMBL24498940 0.81 KMT2A (0.71) KMT2APOLBL3MBTL1MEN1TSHR
SCHEMBL9808278 0.79 ALDH1A1 (0.55) KMT2APOLBTSHRALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115108926-B Intermediate compound for preparing erdasatinib and preparation method 上海工程技术大学 2023-06-20 CN claimed
CN-115108926-A Intermediate compound for preparing erdastinib and preparation method 上海工程技术大学 2022-09-27 CN claimed
WO-2025229046-A1 SUBSTITUTED HYDROQUINOLINES FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME MOLIUS SAGLIK TEKNOLOJILERI ANONIM SIRKETI (TR) 2025-11-06 WO disclosed
EP-4644375-A1 SUBSTITUTED HYDROQUINOLINES FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME Molius Saglik Teknolojileri Anonim Sirketi (TR) 2025-11-05 EP disclosed
US-20240315994-A1 SMALL MOLECULE MODULATORS OF FERROPTOSIS ARPEGGIO BIOSCIENCES, INC. 2024-09-26 US disclosed
CN-115108926-B Intermediate compound for preparing erdasatinib and preparation method 上海工程技术大学 2023-06-20 CN disclosed
CN-115108926-A Intermediate compound for preparing erdastinib and preparation method 上海工程技术大学 2022-09-27 CN disclosed
US-10954197-B2 Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer YOGEE'S BIOINNOVATIONS PRIVATE LIMITED (IN) 2021-03-23 US disclosed
US-20210002337-A1 IN VIVO ENGINEERED CEREBLON PROTEIN THE SCRIPPS RESEARCH INSTITUTE 2021-01-07 US disclosed
US-10781239-B2 In vivo engineered cereblon protein VIVIDION THERAPEUTICS, INC. (US) 2020-09-22 US disclosed
US-20200216507-A1 IN VIVO ENGINEERED CEREBLON PROTEIN VIVIDION THERAPEUTICS, INC. 2020-07-09 US disclosed
US-20060009461-A1 Acetamides and benzamides that are useful in treating sexual dysfunction BHATIA PRAMILA A 2006-01-12 US disclosed
EP-1509213-A2 ACETAMIDES AND BENZAMIDES THAT ARE USEFUL IN TREATING SEXUAL DYSFUNCTION Abbott Laboratories (US) 2005-03-02 EP disclosed
US-20040029887-A1 Acetamides and benzamides that are useful in treating sexual dysfunction ABBOTT LABORATORIES 2004-02-12 US disclosed
US-20030229094-A1 Acetamides and benzamides that are useful in treating sexual dysfunction ABBOTT LABORATORIES 2003-12-11 US disclosed
WO-2003099266-A2 ACETAMIDES AND BENZAMIDES THAT ARE USEFUL IN TREATING SEXUAL DYSFUNCTION ABBOTT LABORATORIES (US) 2003-12-04 WO disclosed
US-4567264-A ADRENERGIC BLOCKING AGENTS SYNTEX (U.S.A.) INC. (US) 1986-01-28 US disclosed
US-4558129-A Benzodioxanyl-hydroxyethylene-piperazinyl acetanilides which effect calcium entry and β-blockade SYNTEX (U.S.A.) INC. (US) 1985-12-10 US disclosed
US-4499100-A CARDIOUVASCULAR DISORDERS SYNTEX (U.S.A.) INC. (US) 1985-02-12 US disclosed
EP-0126449-A1 Cardioselective aryloxy- and arylthio-hydroxypropyl piperazinyl acetanilides wich affect calcium entry SYNTEX (U.S.A.) INC. (US) 1984-11-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030229094-A1 Acetamides and benzamides that are useful in treating sexual dysfunction CATSPER1, CYP19A1, PDE12 KMT2A 2169/4885POLB 3627/4885L3MBTL1 4477/4885
US-20200216507-A1 IN VIVO ENGINEERED CEREBLON PROTEIN CRBN, CDR2, DCUN1D4 KMT2A 607/4885POLB 4179/4885L3MBTL1 167/4885
US-20040029887-A1 Acetamides and benzamides that are useful in treating sexual dysfunction CATSPER1, CYP19A1, PDE12 KMT2A 2169/4885POLB 3627/4885L3MBTL1 4477/4885
US-20240315994-A1 SMALL MOLECULE MODULATORS OF FERROPTOSIS GPX4, GPX1, AIFM2 KMT2A 2780/4885POLB 3938/4885L3MBTL1 1305/4885
US-20060009461-A1 Acetamides and benzamides that are useful in treating sexual dysfunction PDE12, NAAA, CYP19A1 KMT2A 1792/4885POLB 3383/4885L3MBTL1 4625/4885
US-20210002337-A1 IN VIVO ENGINEERED CEREBLON PROTEIN CRBN, CDR2, DCUN1D4 KMT2A 607/4885POLB 4179/4885L3MBTL1 167/4885
US-10954197-B2 Cathepsin-D and angiogenesis inhibitors and compositions thereof for treating breast cancer CTSD, CTSF, CTSG KMT2A 3304/4885POLB 3291/4885L3MBTL1 2229/4885
US-10781239-B2 In vivo engineered cereblon protein CRBN, CDR2, DCUN1D4 KMT2A 607/4885POLB 4179/4885L3MBTL1 167/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.