Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4017031 | 0.82 | MEN1 (0.45) | MEN1KMT2A | |
| SCHEMBL101050 | 0.82 | MEN1 (0.49) | MEN1KMT2A | |
| SCHEMBL4014873 | 0.81 | MEN1 (0.47) | MEN1KMT2A | |
| Potassium Ion SCHEMBL4999730 | 0.79 | NR4A1 (0.33) | MEN1KMT2ANR4A1 | |
| SCHEMBL5699565 | 0.77 | KMT2A (0.41) | MEN1KMT2A | |
| SCHEMBL1049879 | 0.71 | MEN1 (0.55) | MEN1KMT2A | |
| SCHEMBL31461336 | 0.71 | MEN1 (0.55) | MEN1KMT2A | |
| SCHEMBL1369158 | 0.71 | DUSP5 (0.42) | MEN1KMT2A | |
| Potassium Ion SCHEMBL224967 | 0.71 | LMNA (0.41) | MEN1KMT2A | |
| Potassium Ion SCHEMBL29727670 | 0.71 | LMNA (0.41) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1491591-B1 | New fluorescence cyanine labels containing a sulfamido linker arm | VISEN MEDICAL INC (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1065250-B1 | New fluorescent cyanine labels containing a sulfamido linker arm | VISEN MEDICAL INC (US) | 2004-12-08 | — | — | EP | disclosed |
| US-6448008-B1 | IMMUNOLOGICAL BINDING REAGENT LABELLED WITH A FLUORESCENT COMPOUND AND METHOD OF ASSAYING AN ANALYTE IN A SAMPLE COMPRISING CONTACTING A NUCLEIC ACID PROBE OR AN IMMUNOLOGICALLY BINDING REAGENT LABELLED WITH A FLUORESCENT | INNOSENSE, S.R.L. (IT) | 2002-09-10 | — | — | US | disclosed |
| EP-1065250-A1 | New fluorescent cyanine labels containing a sulfamido linker arm | Innosense S.r.l. (IT) | 2001-01-03 | — | — | EP | disclosed |