Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.45 |
| ▸ | TYMS | P04818 | 1/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.36 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.35 |
| ▸ | TUBB | P07437 | 4/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4035892 | 0.89 | TUBB4A (0.44) | RAF1DYRK1APKN1PKN2TUBB4A | |
| SCHEMBL2052736 | 0.86 | RAF1 (0.46) | RAF1DYRK1ATYMSPKN1PKN2 | |
| SCHEMBL4035517 | 0.83 | TYMS (0.37) | TYMSPKN1PKN2SLC6A9 | |
| SCHEMBL3269941 | 0.77 | TYMS (0.41) | DYRK1ATYMSPKN2TUBB4ATUBB | |
| SCHEMBL3839280 | 0.76 | TUBB4A (0.44) | TYMSTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4036538 | 0.76 | JAK2 (0.48) | PKN1PKN2TUBB4ATUBBTUBA3C | |
| SCHEMBL2051287 | 0.74 | TUBB4A (0.50) | RAF1DYRK1APKN1PKN2TUBB4A | |
| SCHEMBL4043016 | 0.74 | ROCK2 (0.40) | DYRK1ATYMSPKN2TUBB4ATUBB | |
| SCHEMBL4035604 | 0.74 | ACHE (0.40) | DYRK1ATYMSPKN2TUBB4ATUBB | |
| SCHEMBL3269989 | 0.74 | KDR (0.39) | TYMSTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |