Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | TYMS | P04818 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207716 | 0.89 | MAPT (0.42) | MAPTSMN1; SMN2LMNAPARP1RAB9A | |
| SCHEMBL4035502 | 0.85 | TUBB4A (0.39) | SMN1; SMN2LMNAPARP1ALDH1A1MEN1 | |
| SCHEMBL4035489 | 0.84 | SLC6A4 (0.43) | SMN1; SMN2LMNAPARP1RAB9AL3MBTL1 | |
| SCHEMBL4032967 | 0.84 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL4033192 | 0.84 | PKN1 (0.38) | PARP1MEN1KMT2ATYMS | |
| SCHEMBL4035321 | 0.84 | MAPT (0.49) | MAPTSMN1; SMN2LMNAPARP1RAB9A | |
| SCHEMBL4034008 | 0.79 | LMNA (0.37) | LMNAPARP1KMT2A | |
| SCHEMBL4036370 | 0.78 | PARP1 (0.37) | PARP1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL4033284 | 0.78 | PTGS1 (0.37) | LMNAPARP1RAB9ANPC1L3MBTL1 | |
| SCHEMBL4033058 | 0.77 | TYMS (0.37) | RAB9ANPC1PKMALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747220-B1 | SUBSTITUTED 1H-PYRROLO[3,2-B, 3,2-C, AND 2,3-C]PYRIDINE-2-CARBOXAMIDES AND RELATED ANALOGS AS INHIBITORS OF CASEIN KINASE I EPSILON | AVENTIS PHARMA INC (US) | 2009-04-15 | — | — | EP | claimed |