Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | BMP1 | P13497 | 5/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 3/20 | 0.31 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP3 | P08254 | 1/20 | 0.31 |
| ▸ | MMP7 | P09237 | 1/20 | 0.31 |
| ▸ | MMP9 | P14780 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.31 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4043593 | 0.91 | USP2 (0.33) | GAAUSP2TRPM8USP30BMP1 | |
| SCHEMBL4049248 | 0.90 | CTSV (0.31) | GAAKCNQ1F2PRSS1KDM4E | |
| SCHEMBL4042354 | 0.90 | TAS1R3 (0.37) | GAATAS1R3TAS1R1ALDH1A1 | |
| SCHEMBL4043432 | 0.90 | KCNQ1 (0.38) | GAAUSP2TRPM8USP30KCNQ1 | |
| SCHEMBL4043383 | 0.90 | TAS1R3 (0.35) | GAAKCNQ1F2PRSS1TAS1R3 | |
| SCHEMBL4049501 | 0.87 | CTSK (0.40) | TRPM8 | |
| SCHEMBL4038978 | 0.84 | USP30 (0.34) | TRPM8USP30BMP1F2 | |
| SCHEMBL4051635 | 0.84 | HPGD (0.37) | GAATRPM8USP30BMP1KDM4E | |
| SCHEMBL4045350 | 0.84 | CHRNB2 (0.34) | TRPM8USP30ALDH1A1 | |
| SCHEMBL4046322 | 0.84 | CHRNB2 (0.38) | TRPM8USP30KCNQ1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |