Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 2/20 | 0.36 |
| ▸ | FAP | Q12884 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | GPR132 | Q9UNW8 | 3/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.32 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.32 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4048898 | 0.92 | CTSK (0.43) | CTSKPOLBPAX8 | |
| SCHEMBL4041238 | 0.92 | CHRNB2 (0.36) | PREPFAPCTSKPAX8ACACB | |
| SCHEMBL4045110 | 0.87 | PREP (0.35) | PREPFAPCTSKPOLB | |
| SCHEMBL4043031 | 0.86 | HTRA1 (0.37) | CTSKPAX8ACACBGPR132HTRA1 | |
| SCHEMBL4047771 | 0.86 | CTSK (0.39) | CTSKACACBGPR132SIGMAR1 | |
| SCHEMBL4044443 | 0.85 | ALDH1A1 (0.38) | PREPFAPCTSKPAX8ACACB | |
| SCHEMBL4047976 | 0.85 | CTSK (0.43) | CTSK | |
| SCHEMBL4043616 | 0.85 | CTSK (0.35) | PREPFAPCTSKPAX8GPR132 | |
| SCHEMBL4046666 | 0.85 | HSD17B10 (0.36) | PREPFAPCTSK | |
| SCHEMBL4046060 | 0.84 | CTSK (0.35) | PREPFAPCTSKPAX8ACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |