Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 4/20 | 0.35 |
| ▸ | CTSL | P07711 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 3/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CTSB | P07858 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045047 | 0.93 | CTSL (0.37) | GAAMAPTNPSR1CTSKCTSL | |
| SCHEMBL4042762 | 0.90 | GAA (0.34) | GAAMAPTNPSR1CTSKCTSL | |
| SCHEMBL4044198 | 0.90 | CTSL (0.42) | GAAMAPTNPSR1CTSKCTSL | |
| SCHEMBL4040381 | 0.88 | MC4R (0.36) | GAAMAPTNPSR1CTSKCTSL | |
| SCHEMBL4044539 | 0.87 | ITGA4 (0.36) | CTSKCTSLCTSSITGA4ITGB7 | |
| SCHEMBL4041745 | 0.86 | CNR1 (0.39) | GAAMAPTNPSR1CTSKCTSL | |
| SCHEMBL4042222 | 0.85 | CNR1 (0.34) | GAAMAPTNPSR1CTSKCTSL | |
| SCHEMBL4044157 | 0.85 | CNR1 (0.38) | GAAMAPTNPSR1CTSKCTSL | |
| SCHEMBL4052351 | 0.85 | CNR1 (0.36) | GAAMAPTNPSR1CTSKITGA4 | |
| SCHEMBL4049994 | 0.85 | CTSK (0.40) | GAAMAPTNPSR1CTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |