Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | MAOA | P21397 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145996 | 0.89 | SMN1; SMN2 (0.51) | MAOBMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3009674 | 0.84 | HPGD (0.59) | MAOBMAOANPC1RAB9ASMN1; SMN2 | |
| Thiourea SCHEMBL6715523 | 0.82 | SMN1; SMN2 (0.46) | MAOBMAOANPC1RAB9ASMN1; SMN2 | |
| Iodoacetamide SCHEMBL2218893 | 0.81 | SMN1; SMN2 (0.48) | MAOBMAOANPC1RAB9ASMN1; SMN2 | |
| Acetic Acid SCHEMBL28312963 | 0.80 | MAOB (0.58) | MAOBMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3933571 | 0.77 | PGR (0.47) | MAOBMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13041713 | 0.77 | CYP19A1 (0.69) | MAOBNPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL1619109 | 0.76 | MAOB (0.67) | MAOBMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30594160 | 0.76 | MAOB (0.67) | MAOBMAOANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30241252 | 0.75 | MAOB (0.54) | MAOBMAOANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8324173-B2 | Peptides useful as dual caspase-2/-6 inhibitors and their biological applications | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-12-04 | — | — | US | disclosed |
| US-8173600-B2 | Caspase-2 inhibitors and their biological applications | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-05-08 | — | — | US | disclosed |
| US-20120021990-A1 | PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | CHAUVIER DAVID (FR) | 2012-01-26 | — | — | US | disclosed |
| WO-2009083930-A1 | CASPASE-8 INHIBITORS AND USES THEREOF | THERAPTOSIS (FR) | 2009-07-09 | — | — | WO | disclosed |
| WO-2009083929-A1 | CASPASE-1 INHIBITORS AND USES THEREOF | THERAPTOSIS (FR) | 2009-07-09 | — | — | WO | disclosed |
| US-20090042805-A1 | Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-02-12 | — | — | US | disclosed |
| US-20080311051-A1 | Caspase-2 Inhibitors And Their Biological Applications | THERAPTOSIS SA (FR) | 2008-12-18 | — | — | US | disclosed |
| EP-1817328-A2 | NEW PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | Theraptosis S.A. (FR) | 2007-08-15 | — | — | EP | disclosed |
| WO-2006056487-A2 | PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | THERAPTOSIS S.A. (FR) | 2006-06-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042805-A1 | Peptides Useful As Dual Caspase-2/-6 Inhibitors And Their Biological Applications | CASP6, CASP2, CASP4 | MAOB 4622/4885MAOA 4720/4885NPC1 4148/4885 |
| US-20080311051-A1 | Caspase-2 Inhibitors And Their Biological Applications | CASP1, CASP2, CASP9 | MAOB 3906/4885MAOA 4454/4885NPC1 2570/4885 |
| US-20120021990-A1 | PEPTIDES USEFUL AS DUAL CASPASE-2/-6 INHIBITORS AND THEIR BIOLOGICAL APPLICATIONS | CASP6, CASP2, CASP1 | MAOB 3892/4885MAOA 4333/4885NPC1 3906/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.