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Ribose (Furanose)

Ribose (Furanose)

SCHEMBL4077632

Nc1ncnc2[nH]nc(I)c12.OC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADK P55263 9/20 0.52
▸ DOT1L Q8TEK3 3/20 0.52
▸ CDK5 Q00535 2/20 0.52
▸ DCLK1 O15075 1/20 0.52
▸ DAPK3 O43293 1/20 0.52
▸ DYRK3 O43781 1/20 0.52
▸ CDK1 P06493 1/20 0.52
▸ ROS1 P08922 1/20 0.52
▸ RPS6KB1 P23443 1/20 0.52
▸ CDK2 P24941 1/20 0.52
▸ FLT3 P36888 1/20 0.52
▸ CSNK1A1 P48729 1/20 0.52
▸ CSNK1D P48730 1/20 0.52
▸ CLK2 P49760 1/20 0.52
▸ IRAK1 P51617 1/20 0.52
▸ DYRK1A Q13627 1/20 0.52
▸ MELK Q14680 1/20 0.52
▸ NTRK3 Q16288 1/20 0.52
▸ HIPK4 Q8NE63 1/20 0.52
▸ SLK Q9H2G2 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ribose (Furanose) SCHEMBL5576202 1.00 ADK (0.52) ADKDOT1LCDK5DCLK1DAPK3
Ribose (Furanose) SCHEMBL5576201 0.82 ADK (0.49) ADKDOT1LCDK5DCLK1DAPK3
Ribose (Furanose) SCHEMBL4077631 0.82 ADK (0.49) ADKDOT1LCDK5DCLK1DAPK3
SCHEMBL8801 0.78 PIK3CD (0.42) DYRK3CSNK1DMEN1PI4KAKMT2A
Ribose (Furanose) SCHEMBL4079014 0.74 PI4KA (0.58) ADKDOT1LCDK5DCLK1DAPK3
Ribose (Furanose) SCHEMBL4085700 0.74 PI4KA (0.58) ADKDOT1LCDK5DCLK1DAPK3
Ribose (Furanose) SCHEMBL8324675 0.74 ADA (0.41) ADKDOT1LCDK1ALDH1A1HIF1A
SCHEMBL638909 0.74 UMPS (0.39) ADKDOT1LCDK5DCLK1DAPK3
Adenine SCHEMBL14636444 0.73 HIF1A (0.49) ADKDOT1LHIF1ADPP4MEN1
Ribose (Furanose) SCHEMBL4083364 0.71 HIF1A (0.47) ADKDOT1LCDK5DCLK1DAPK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7491818-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2009-02-17 — — US disclosed
US-7179905-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2007-02-20 — — US disclosed
US-6965020-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2005-11-15 — — US disclosed
US-20050164268-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2005-07-28 — — US disclosed
US-6844433-B2 Nucleic acid labeling compounds AFFYMETRIX, INC. (US) 2005-01-18 — — US disclosed
US-20040210045-A1 Nucleic acid labeling compounds MCGALL GLENN (US) 2004-10-21 — — US disclosed
US-20040002595-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2004-01-01 — — US disclosed
US-20030232979-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2003-12-18 — — US disclosed
US-6596856-B2 For probes, comprising a heterocycle condensed with a cyclic group such as ribofuranose derivative; biotin and 5-carboxyfluorescein derivatives AFFYMETRIX, INC. 2003-07-22 — — US disclosed
US-20020165372-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2002-11-07 — — US disclosed
US-20010044531-A1 Nucleic acid labeling compounds AFFYMETRIX, INC. 2001-11-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040002595-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ADK 454/4885DOT1L 955/4885CDK5 797/4885
US-20050164268-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ADK 454/4885DOT1L 955/4885CDK5 797/4885
US-20010044531-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ADK 454/4885DOT1L 955/4885CDK5 797/4885
US-20020165372-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ADK 454/4885DOT1L 955/4885CDK5 797/4885
US-20030232979-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ADK 454/4885DOT1L 955/4885CDK5 797/4885
US-20040210045-A1 Nucleic acid labeling compounds RNGTT, DUT, FBL ADK 454/4885DOT1L 955/4885CDK5 797/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.