Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091779 | 0.90 | LMNA (0.44) | SMN1; SMN2ELANEKDM4EMAPTALDH1A1 | |
| SCHEMBL4078418 | 0.90 | HTT (0.43) | SMN1; SMN2ELANEKDM4EMAPTALDH1A1 | |
| SCHEMBL4088241 | 0.89 | ELANE (0.48) | SMN1; SMN2TDP1ELANEKDM4EMAPT | |
| SCHEMBL4083791 | 0.85 | LMNA (0.44) | SMN1; SMN2POLBKDM4EMAPTALDH1A1 | |
| SCHEMBL4088637 | 0.85 | ALDH1A1 (0.43) | SMN1; SMN2ELANEKDM4EMAPTALDH1A1 | |
| SCHEMBL4083509 | 0.84 | GPR35 (0.49) | SMN1; SMN2POLBELANEKDM4ECYP1A2 | |
| SCHEMBL4084033 | 0.84 | ELANE (0.45) | ELANEALDH1A1LMNATSHRGPR35 | |
| SCHEMBL4083252 | 0.84 | PTK2 (0.37) | SMN1; SMN2TDP1ELANEKDM4EMAPT | |
| SCHEMBL4088619 | 0.83 | GPR35 (0.42) | ELANEMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL4083134 | 0.83 | GPR35 (0.42) | SMN1; SMN2ELANEKDM4ECYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |