Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 3/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078418 | 0.88 | HTT (0.43) | ALDH1A1NPC1RAB9ASMN1; SMN2MAOB | |
| SCHEMBL4091779 | 0.86 | LMNA (0.44) | GPR35ALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL4088637 | 0.86 | ALDH1A1 (0.43) | GPR35ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4084033 | 0.85 | ELANE (0.45) | GPR35ALDH1A1NPC1MAOBMAPK1 | |
| SCHEMBL4083509 | 0.85 | GPR35 (0.49) | GPR35ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4087183 | 0.84 | RAB9A (0.45) | ALDH1A1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4078227 | 0.84 | PAX8 (0.45) | GPR35ALDH1A1NPC1SMN1; SMN2MEN1 | |
| SCHEMBL4078733 | 0.84 | ALDH1A1 (0.44) | GPR35ALDH1A1SMN1; SMN2MAPK1L3MBTL1 | |
| SCHEMBL4084062 | 0.84 | ALDH1A1 (0.51) | ALDH1A1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4088619 | 0.83 | GPR35 (0.42) | GPR35ALDH1A1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |