Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 8/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | SLC26A6 | Q9BXS9 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078418 | 0.88 | HTT (0.43) | ELANEALDH1A1MAOBLMNATSHR | |
| SCHEMBL4088637 | 0.86 | ALDH1A1 (0.43) | ELANECASP3SENP8SENP7SENP6 | |
| SCHEMBL4091779 | 0.86 | LMNA (0.44) | ELANEGPR35ALDH1A1LMNAADORA3 | |
| SCHEMBL4083509 | 0.85 | GPR35 (0.49) | ELANEGPR35ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL4083252 | 0.85 | PTK2 (0.37) | ELANEADORA2BGPR35ALDH1A1MAOB | |
| SCHEMBL4078227 | 0.84 | PAX8 (0.45) | ELANEGPR35ALDH1A1LMNATSHR | |
| SCHEMBL4078733 | 0.84 | ALDH1A1 (0.44) | ELANEGPR35ALDH1A1MAPK1LMNA | |
| SCHEMBL4078553 | 0.84 | KDM4E (0.44) | ALDH1A1MAPK1LMNATSHRL3MBTL1 | |
| SCHEMBL4084041 | 0.84 | RAB9A (0.45) | CASP3SENP8SENP7SENP6ALDH1A1 | |
| SCHEMBL4083915 | 0.84 | MAP3K5 (0.37) | ELANEALDH1A1MAOBMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |