Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | F2R | P25116 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084092 | 0.89 | ALDH1A1 (0.49) | ALDH1A1KDM4ESMN1; SMN2MAPTTP53 | |
| SCHEMBL10072013 | 0.88 | MAOB (0.36) | LMNAALDH1A1KDM4ESMN1; SMN2TP53 | |
| SCHEMBL4078418 | 0.87 | HTT (0.43) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4091779 | 0.85 | LMNA (0.44) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4084026 | 0.85 | MAPT (0.42) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4078227 | 0.85 | PAX8 (0.45) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4078532 | 0.85 | RAB9A (0.39) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4084062 | 0.85 | ALDH1A1 (0.51) | ALDH1A1KDM4ESMN1; SMN2MAPTTP53 | |
| SCHEMBL4087183 | 0.84 | RAB9A (0.45) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT | |
| SCHEMBL4093454 | 0.83 | JMJD6 (0.38) | LMNAALDH1A1KDM4ESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |