Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.42 |
| ▸ | DAO | P14920 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | PTPRG | P23470 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11325227 | 0.87 | GPR35 (0.39) | GPR35DAOGSK3BPOLBTDP1 | |
| SCHEMBL6596838 | 0.84 | GPR35 (0.42) | GPR35DAOGSK3BPOLBTDP1 | |
| SCHEMBL13887939 | 0.84 | GSK3B (0.38) | DAOGSK3BKDM4EGAA | |
| SCHEMBL4885038 | 0.79 | GPR35 (0.36) | GPR35GSK3BPOLBTDP1L3MBTL1 | |
| SCHEMBL6629996 | 0.78 | KMT2A (0.38) | GPR35DAOGSK3BPOLBTDP1 | |
| SCHEMBL5207266 | 0.78 | GSK3B (0.46) | GPR35DAOGSK3BPOLBTDP1 | |
| SCHEMBL9405491 | 0.77 | MEN1 (0.44) | DAOL3MBTL1PTPRCKMT2AMCL1 | |
| SCHEMBL2470504 | 0.76 | ALDH1A1 (0.44) | GPR35DAOGSK3BPOLBTDP1 | |
| SCHEMBL27595406 | 0.76 | GPR35 (0.31) | GPR35PTPRCPTPRG | |
| SCHEMBL3636522 | 0.75 | L3MBTL1 (0.52) | GPR35DAOGSK3BPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4201778-A | 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates | SCHERING CORPORATION (US) | 1980-05-06 | — | — | US | claimed |
| US-8354418-B2 | Thiazolyl-dihydro-quinazolines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-15 | — | — | US | disclosed |
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-21 | — | — | US | disclosed |
| US-7517995-B2 | Thiazolyl-dihydro-cyclopentapyrazole | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-14 | — | — | US | disclosed |
| EP-2007772-A1 | THIAZOLYL-DIHYDROQUINAZOLINES | Boehringer Ingelheim International GmbH (DE) | 2008-12-31 | — | — | EP | disclosed |
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
| WO-2007115932-A1 | THIAZOLYL-DIHYDROQUINAZOLINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-18 | — | — | WO | disclosed |
| US-20070238746-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
| US-20070238730-A1 | THIAZOLYL-DIHYDRO-CYCLOPENTAPYRAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-10-11 | — | — | US | disclosed |
| US-20050226844-A1 | Valency platform molecules comprising carbamate linkages | LA JOLLA PHARMACEUTICAL COMPANY (US) | 2005-10-13 | — | — | US | disclosed |
| US-6458953-B1 | VALENCY PLATFORM MOLECULES WHICH ACT AS SCAFFOLDS TO WHICH ONE OR MORE MOLECULES MAY BE COVALENTLY TETHERED TO FORM A CONJUGATE. MORE PARTICULARLY, THE PRESENT INVENTION PERTAINS TO VALENCY PLATFORM MOLECULES WHICH COMPRISE A CARBAMATE | LA JOLLA PHARMACEUTICAL COMPANY | 2002-10-01 | — | — | US | disclosed |
| EP-1137628-A1 | MOLECULAR SCAFFOLDS ACTING AS TEMPLATES COMPRISING CARBAMATE LINKAGES | LA JOLLA PHARMACEUTICAL COMPANY (CA) | 2001-10-04 | — | — | EP | disclosed |
| EP-1037905-A1 | ANTIPICORNAVIRAL COMPOUNDS AND METHODS FOR THEIR USE AND PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-2000034231-A1 | MOLECULAR SCAFFOLDS ACTING AS TEMPLATES COMPRISING CARBAMATE LINKAGES | LA JOLLA PHARMACEUTICAL COMPANY (US) | 2000-06-15 | — | — | WO | disclosed |
| US-5962487-A | PICORNAVIRAL 3C PROTEASE INHIBITORS | AGOURON PHARMACEUTICALS, INC. (US) | 1999-10-05 | — | — | US | disclosed |
| WO-1999031122-A9 | ANTIPICORNAVIRAL COMPOUNDS AND METHODS FOR THEIR USE AND PREPARATION | AGOURON PHARMA (US) | 1999-09-30 | — | — | WO | disclosed |
| WO-1999031122-A1 | ANTIPICORNAVIRAL COMPOUNDS AND METHODS FOR THEIR USE AND PREPARATION | AGOURON PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |
| US-4965368-A | USED FOR THIOLCARBAMATES | ICI AMERICAS INC. (US) | 1990-10-23 | — | — | US | disclosed |
| EP-0021759-A1 | 5-Substituted oxazolidines having herbicide antidote activity, production thereof, herbicidal compositions containing them, use thereof in preventing injury to crops and crop seeds coated therewith | STAUFFER CHEMICAL COMPANY (US) | 1981-01-07 | — | — | EP | disclosed |
| US-4201778-A | 6-Acyloxy-1,4,6-pregnatrienes, their use as anti-inflammatory agents, methods for their manufacture, and 6-oxo-1,4-pregnadiene intermediates | SCHERING CORPORATION (US) | 1980-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050226844-A1 | Valency platform molecules comprising carbamate linkages | NEDD8, CYP2C8, VIM | GPR35 2879/4885DAO 135/4885GSK3B 3444/4885 |
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | ROR1, RORB, RORA | GPR35 310/4885DAO 1544/4885GSK3B 322/4885 |
| US-20070238746-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | CYP3A7, UGT2B7, UGT1A7 | GPR35 525/4885DAO 657/4885GSK3B 644/4885 |
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | CYP3A7, UGT2B7, UGT1A7 | GPR35 525/4885DAO 657/4885GSK3B 644/4885 |
| US-20070238730-A1 | THIAZOLYL-DIHYDRO-CYCLOPENTAPYRAZOLE | REN, ROR1, RORB | GPR35 394/4885DAO 2101/4885GSK3B 429/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.