Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.37 |
| ▸ | ITK | Q08881 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4091779 | 0.88 | LMNA (0.44) | ALDH1A1SMN1; SMN2KDM4EELANEP2RY14 | |
| SCHEMBL4088637 | 0.88 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KDM4EELANEGPR35 | |
| SCHEMBL4078418 | 0.88 | HTT (0.43) | ALDH1A1SMN1; SMN2KDM4EELANEMAPT | |
| SCHEMBL4083509 | 0.88 | GPR35 (0.49) | ALDH1A1SMN1; SMN2KDM4EELANEGPR35 | |
| SCHEMBL4088619 | 0.85 | GPR35 (0.42) | ALDH1A1ELANEGPR35MAPTMAPK14 | |
| SCHEMBL4083134 | 0.85 | GPR35 (0.42) | ALDH1A1SMN1; SMN2KDM4EELANEGPR35 | |
| SCHEMBL4084033 | 0.84 | ELANE (0.45) | ALDH1A1ELANEGPR35LMNATSHR | |
| SCHEMBL4083252 | 0.84 | PTK2 (0.37) | ALDH1A1SMN1; SMN2KDM4EELANEGPR35 | |
| SCHEMBL4086291 | 0.84 | MAPK1 (0.44) | SMN1; SMN2KDM4EPOLBMAPTLMNA | |
| SCHEMBL4091205 | 0.84 | LRRK2 (0.46) | ALDH1A1SMN1; SMN2KDM4EPKMBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |