Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | SRPK1 | Q96SB4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088668 | 0.90 | SMN1; SMN2 (0.54) | RAB9ATSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL4091205 | 0.83 | LRRK2 (0.46) | RAB9ATSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL4083518 | 0.83 | LMNA (0.44) | RAB9ATSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL4086291 | 0.83 | MAPK1 (0.44) | RAB9ATSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL4093445 | 0.82 | LMNA (0.44) | RAB9ATSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL3887134 | 0.82 | ALDH1A1 (0.43) | RAB9ATSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL4082722 | 0.82 | RAB9A (0.43) | RAB9ATSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL4087183 | 0.79 | RAB9A (0.45) | RAB9ATSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL4078418 | 0.79 | HTT (0.43) | RAB9ATSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL4083862 | 0.79 | TAS1R3 (0.38) | RAB9ATSHRSMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |