Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083791 | 0.89 | LMNA (0.44) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL10072013 | 0.87 | MAOB (0.36) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPK1 | |
| SCHEMBL4078418 | 0.86 | HTT (0.43) | ALDH1A1HPGDSMN1; SMN2KDM4ETSHR | |
| SCHEMBL4084026 | 0.84 | MAPT (0.42) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4083509 | 0.84 | GPR35 (0.49) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL4078532 | 0.84 | RAB9A (0.39) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4084062 | 0.84 | ALDH1A1 (0.51) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4087183 | 0.83 | RAB9A (0.45) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 | |
| SCHEMBL4091779 | 0.83 | LMNA (0.44) | ALDH1A1HPGDSMN1; SMN2KDM4EMAPT | |
| SCHEMBL4078553 | 0.82 | KDM4E (0.44) | ALDH1A1HPGDSMN1; SMN2KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |