Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.51 |
| ▸ | HPGD | P15428 | 9/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | PKM | P14618 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084026 | 0.88 | MAPT (0.42) | ALDH1A1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4087183 | 0.86 | RAB9A (0.45) | ALDH1A1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4083791 | 0.85 | LMNA (0.44) | ALDH1A1HPGDRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4078418 | 0.84 | HTT (0.43) | ALDH1A1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4083862 | 0.84 | TAS1R3 (0.38) | ALDH1A1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4084092 | 0.84 | ALDH1A1 (0.49) | ALDH1A1HPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4083252 | 0.84 | PTK2 (0.37) | ALDH1A1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL10072013 | 0.83 | MAOB (0.36) | ALDH1A1HPGDRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4091779 | 0.83 | LMNA (0.44) | ALDH1A1HPGDRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4093521 | 0.83 | SMN1; SMN2 (0.43) | ALDH1A1HPGDRAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |