Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.45 |
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | PKM | P14618 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.45 |
| ▸ | RELA | Q04206 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078553 | 0.85 | KDM4E (0.44) | RAB9ANPC1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL4078418 | 0.84 | HTT (0.43) | RAB9ANPC1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL4083862 | 0.84 | TAS1R3 (0.38) | RAB9ANPC1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL4084026 | 0.84 | MAPT (0.42) | RAB9ANPC1HPGDPKMSMN1; SMN2 | |
| SCHEMBL4083509 | 0.84 | GPR35 (0.49) | RAB9ANPC1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL4084033 | 0.84 | ELANE (0.45) | NPC1ALDH1A1CASP3SENP8SENP7 | |
| SCHEMBL4091779 | 0.83 | LMNA (0.44) | RAB9AHPGDSMN1; SMN2KMT2AMAPT | |
| SCHEMBL4093521 | 0.83 | SMN1; SMN2 (0.43) | RAB9ANPC1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL4087183 | 0.83 | RAB9A (0.45) | RAB9ANPC1HPGDSMN1; SMN2MEN1 | |
| SCHEMBL4088637 | 0.83 | ALDH1A1 (0.43) | RAB9ANPC1HPGDSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |